摘要
【目的】女性妊娠期相关精神疾病的神经机制尚不清楚,本研究拟探究妊娠期应激诱发的相关精神疾病发病与海马突触可塑性的关系。【方法】对大鼠施行束缚应激后,采用在体麻醉电生理学方法检测大鼠海马CA1区的兴奋性突触后电位,比对经历应激和未应激妊娠期大鼠海马突触可塑性的变化。【结果】与未妊娠空白对照组相比,低频刺激诱导后未应激的妊娠期大鼠可形成长时程增强(long-term potentiation,LTP)。此外,施行束缚应激的妊娠期大鼠,则表现为长时程抑制(long-term depression, LTD)不能形成。【结论】妊娠期内应激使海马突触可塑发生异常,为妊娠期相关精神疾病发病机制的进一步研究提供了突触可塑性异常的重要线索。
[Purpose]The neural mechanism of female pregnancy-related mental illness remains unclear.We aimed to investigate the relationship between stress-related pregnancy-induced mental illness and hippocampal synaptic plasticity.[Methods]After restraint stress on rats,in vivo anesthesia electrophysiology was used to detect the excitatory post-synaptic potentials in the hippocampus of rats,and to compare the changes in hippocampal synaptic plasticity in rats undergoing stress and unstressed pregnancy.[Results]Compared with the non-pregnant blank control group,the longterm potentiation(LTP)was formed in unstressed pregnant rats induced by low frequency stimulation.In addition,the gestational rats undergoing restraint stress showed no long-term depression(LTD)formation.[Conclusion]Stress during pregnancy causes abnormal synaptic plasticity in the hippocampus,which provides important clues for further research on the pathogenesis of pregnancy-related mental diseases.
作者
白华毅
刘婷婷
邓卓凡
何成芸
宋春莲
程美玲
BAI Huayi;LIU Tingting;DENG Zhuofan;HE Chengyun;SONG Chunlian;CHENG Meiling(Basic Veterinary Department,College of Veterinary Medicine,Yunnan Agricultural University,Kunming 650201,China)
出处
《云南农业大学学报（自然科学版）》
CAS
CSCD
北大核心
2021年第2期223-228,共6页
Journal of Yunnan Agricultural University:Natural Science
基金
国家自然科学基金项目(31360247)。
关键词
束缚应激
海马突触可塑性
长时程抑制
长时程增强
restraint stress
hippocampal synaptic plasticity
long-term depression
long-term potentiation
作者简介
白华毅(1978-),男,云南昆明人,博士,讲师,主要从事精神疾病动物模型构建及脑高级功能方面的研究。E-mail:baihuayi@126.com;通信作者:程美玲(1975-),女,甘肃武威人,硕士,副教授,主要从事动物营养生理方面的研究。E-mail:814880470@qq.com。
