摘要
目的探讨血清维生素水平与肺癌患病风险之间的关系。方法纳入肺癌患者222例作为肺癌组,选取同期住院健康体检人群62例作为对照组,比较两组受试者9种血清维生素水平。将两组比较差异有统计学意义的指标纳入多因素logistic回归分析探讨肺癌患病风险的相关因素,构建肺癌患病风险预测模型,并采用受试者工作特征(ROC)曲线进行风险预测效能评估。结果肺癌组受试者血清维生素B1、维生素B2及维生素D水平低于对照组,血清维生素B9、维生素B12及维生素E水平高于对照组(P<0.05)。多因素logistic回归分析结果显示,维生素D是肺癌患病风险的保护性因素(P<0.001),而维生素B12和维生素E是肺癌患病风险的危险因素(P<0.05)。肺癌患病风险预测模型评分=维生素B12(pg/ml)×1.458+维生素D(nmol/L)×(-1.106)+维生素E(μg/ml)×0.819。ROC曲线分析结果显示,维生素B12、维生素D及维生素E预测肺癌患病风险的ROC曲线下面积(AUC)分别为0.820、0.784、0.748,三者联合预测的AUC为0.855。结论血清维生素水平在肺癌患者及健康人群中存在差异,其中维生素B12、维生素E、维生素D是肺癌患病的独立风险预测因素,基于血清维生素水平构建的肺癌患病风险预测模型值得进一步在大规模人群中验证及推广。
Objective To investigate the relationship between serum level of vitamins and risk of lung cancer.Methods A total of 222 patients with lung cancer(lung cancer patients group)and 62 healthy people(control group)were included.Serum level of vitamins were compared between the two groups.Indexes with significant differences between the two groups were included in multivariate logistic regression analysis to explore relevant factors of lung cancer,and a risk prediction model for lung cancer was established.In addition,receiver operating characteristic(ROC)curve was used to evaluate effectiveness of risk prediction for lung cancer.Results Serum levels of vitamin B1,vitamin B2 and vitamin D in lung cancer gourp were lower than those in control group,serum levels of vitamin B9,vitamin B12 and vitamin E in lung cancer group were higher than those in control group(P<0.05).Multivariate logistic regression analysis showed that vitamin D was a protective factor for the risk prediction of lung cancer(P<0.001).While vitamin B12 and vitamin E were risk factors for lung cancer(P<0.05).Risk prediction of lung cancer model score=vitaminB12(pg/ml)×1.458+vitamin D(nmol/L)×(-1.106)+vitamin E(μg/ml)×0.819.ROC curve analysis showed that the areas under ROC curve(AUC)of vitamin B12,vitamin D and vitamin E were 0.820,0.784 and 0.748 respectively.AUC of the above three indexes combined was 0.855.Conclusion There are differences of serum level of vitamins between lung cancer patients and healthy people,vitamin B12,vitamin E and vitamin D are independent risk prediction factors for lung cancer.Further validation of the model for lung cancer risk prediction based on serum vitamin levels is warranted in large populations.
作者
祁春艳
齐晓光
Qi Chunyan;Qi Xiaoguang(Department of Special Ward,Chinese PLA General Hospital,Beijing 100853,China;不详)
出处
《临床内科杂志》
CAS
2021年第3期185-188,共4页
Journal of Clinical Internal Medicine
关键词
肺癌
维生素水平
患病风险
Lung cancer
Serum vitamin blood concentration
Risk of disease
作者简介
通讯作者:齐晓光,E-mail:qxg2010@163.com。
