摘要
目的观察针刺联合常规西药治疗阵发性室上性心动过速(PSVT)临床疗效及对血浆血管性血友病因子(vWF)、一氧化氮(NO)的影响。方法将106例PSVT患者随机分为对照组和研究组,每组53例,同期纳入60例健康体检者作为健康对照组。对照组给予索他洛尔口服,研究组在对照组治疗的基础上联合针刺治疗。观察研究组和对照组临床疗效、不良反应率,3组治疗前后心率、血压、心功能指标[左心室射血分数(LVEF)、校正QT离散度(QTcd)、T波峰末间期(Tpe)]、血浆vWF和NO水平。结果研究组治疗总有效率(94.3%)较对照组(75.5%)高(P<0.05)。治疗前研究组和对照组心率、收缩压、舒张压高于健康对照组(P<0.05),治疗后研究组心率、收缩压、舒张压低于对照组(P<0.05)。治疗前研究组和对照组QTcd、Tpe高于健康对照组(P<0.05),LVEF低于健康对照组(P<0.05);治疗后研究组QTcd、Tpe低于对照组(P<0.05),LVEF高于对照组(P<0.05)。治疗前研究组和对照组血浆vWF水平高于健康对照组(P<0.05),NO水平低于健康对照组(P<0.05);治疗后研究组血浆vWF水平低于对照组(P<0.05),NO水平高于对照组(P<0.05)。研究组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论针刺联合常规西药治疗PSVT,可改善患者心率和血压,促进心肌复极,疗效显著;针刺联合常规西药发挥作用机制可能为降低vWF、提高NO。
Objective To observe the clinical efficacy of acupuncture plus conventional Western medication in treating paroxysmal supraventricular tachycardia(PSVT)and its effects on plasma von Willebrand factor(vWF)and nitric oxide(NO).Method A total of 106 PSVT patients were randomized into a control group and a research group,with 53 cases in each group.Meanwhile,60 healthy subjects were recruited as the healthy control group.The control group was given Sotalol oral liquid,and the research group was treated with acupuncture in addition to the treatment given to the control group.The clinical efficacy and adverse reaction rate were observed in the research group and the control group.Heart rate,blood pressure,cardiac function parameters[left ventricular ejection fraction(LVEF),corrected QT dispersion(QTcd)and T-wave peak-to-end interval(Tpe)],and plasma vWF and NO levels were observed in all three groups.Result The total effective rate in the research group(94.3%)was higher than that in the control group(75.5%)(P<0.05).Before treatment,the heart rate,systolic blood pressure and diastolic blood pressure were higher in the research group and control group than in the healthy control group(P<0.05);the heart rate,systolic blood pressure and diastolic blood pressure in the research group were lower than those in the control group after treatment(P<0.05).Before treatment,the QTcd and Tpe were higher and LVEF was lower in the research and control groups than in the healthy control group(P<0.05);the QTcd and Tpe were lower and LVEF was higher in the research group than in the control group after treatment(P<0.05).The plasma vWF level was higher and the level of NO was lower in the research and control groups than in the healthy control group before treatment(P<0.05);the plasma vWF level was lower and the NO level was higher in the research group than in the control group after treatment(P<0.05).There was no statistically significance comparing the adverse reaction rate between the research group and the control group(P>0.05).Conclusion Acupuncture combined with conventional Western medication can improve the heart rate and blood pressure,promote myocardial repolarization,and produce significant efficacy in treating PSVT,and the mechanism may be the down-regulation of vWF and up-regulation of NO.
作者
陈广
陈培俊
吴晓玉
CHEN Guang;CHEN Pei-jun;WU Xiao-yu(Wenling Hospital of Traditional Chinese Medicine,Taizhou 317500,China;Taizhou First People’s Hospital,Taizhou 318020,China)
出处
《上海针灸杂志》
2021年第3期253-257,共5页
Shanghai Journal of Acupuncture and Moxibustion
关键词
针刺疗法
针药并用
心动过速
室上
血管性血友病因子
一氧化氮
Acupuncture therapy
Acupuncture medication combined
Tachycardia,supraventricular
Von Willebrand factor
Nitric oxide
作者简介
陈广(1986-),男,主治医师,Email:103400521@qq.com;通信作者:陈培俊(1984-),男,副主任医师,Email:34371867@qq.com。
