摘要
Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.
基金
supported by grants from the Ministry of Science and Technology of the People’s Republic of China[grant nos.2016YFC1305600,2016YFC1305202,2016YFC1304904,2017YFC1310700,2018YFC1311800]
the National Natural Science Foundation of China[grant nos.81970706,81970691,81970728,81800683]。
作者简介
the first author:ZHU Yuan Yue,female,born in 1995,MDZ majoring in clinical epidemiology of diabetes and metabolic diseases,These authors contributed equally to this work;the first author:ZHENG Rui Zhi,male,born in 1987,PhD,majoring in epidemiology of metabolic disease,These authors contributed equally to this work;the first author:WANG Gui Xia,female,born in 1963,Professor,majoring in diagnosis and treatment of metabolic diseases,These authors contributed equally to this work;CHEN Li,female,born in 1958,Professor,majoring in diagnosis and treatment of endocrine diseases,These authors contributed equally to this work;Correspondence should be addressed to LI Mian,MD,PhD,E-mail:limian39@aliyun.com;Correspondence should be addressed to LU Jie Li,MD,PhD,E-mail:jielilu@hotmail.com;Correspondence should be addressed to BI Yu Fang,MD,PhD,Tel:86-21-64370045,Fax:86-21-64373514,E-mail:byf10784@rjh.com.cn。
