摘要
胰腺癌是目前预后较差的癌症之一。长链非编码RNA(LncRNA)在胰腺癌的诊断、治疗及预后判断中发挥了重要作用。基因间长链非编码RNA-重编码调控因子(Linc-RoR)作为lncRNA家族的重要成员,在胰腺癌中也发挥了重要作用。Linc-RoR在胰腺癌中高表达并促进胰腺癌细胞的增殖、迁移、侵袭、耐药性。Linc-RoR还参与胰腺癌干细胞的干性维持,并与胰腺癌的预后密切相关。Linc-RoR有望成为胰腺癌新型生物标志物和基因治疗靶点,为胰腺癌的临床治疗带来新的希望。
Pancreatic cancer is currently one of the cancers with a poor prognosis.Long non-coding RNA(LncRNA)plays an important role in the diagnosis,treatment and prognosis of pancreatic cancer.As an important member of the lncRNA family,intergenic long non-coding RNA-recoding regulatory factor(Linc-RoR)also plays an important role in pancreatic cancer.Linc-RoR is highly expressed in pancreatic cancer and promotes the proliferation,migration,invasion and drug resistance of pancreatic cancer cells.Linc-RoR is also involved in the stemness maintenance of pancreatic cancer stem cells,and is closely related to the prognosis of pancreatic cancer.Linc-RoR is expected to become a new biomarker and gene therapy target for pancreatic cancer,bringing new hope to the clinical treatment of pancreatic cancer.
作者
王倩倩
王慧之
徐岷
WANG Qianqian;WANG Huizhi;XU Min(College of Medicine,Jiangsu University,Jiangsu Province,Zhenjiang 212000,China;Department of Gastroenterology,Affiliated Hospital of Jiangsu University,Jiangsu Province,Zhenjiang 212000,China)
出处
《中国医药导报》
CAS
2021年第6期63-66,共4页
China Medical Herald
基金
江苏省自然科学基金资助项目(BK20171305)
江苏省大学生创新创业训练计划项目(202010299234Y)。
关键词
长链非编码RNA
基因间长链非编码RNA-重编码调控因子
胰腺癌
信号通路
Long intergenic non-coding RNA
Long intergenic non-protein coding RNA-regulator of reprogramming
Pancreatic cancer
Cell signaling
作者简介
通讯作者:徐岷(1974.10-),男,博士,主任医师,教授,博士生导师,江苏大学附属医院消化内科主任,研究方向:消化道肿瘤。
