摘要
目的探讨帕罗西汀治疗伴发抑郁的2型糖尿病患者的临床疗效。方法于2018年12月~2019年12月本院纳入的98例2型糖尿病伴发抑郁症患者作为研究对象。根据电脑随机分组法,每个组49例患者,常规组予以常规治疗,研究组则在常规治疗基础上加用帕罗西汀。结果研究组临床疗效高于常规组(P<0.05);研究组空腹血糖、餐后2h血糖、糖化血红蛋白、三酰甘油、总胆固醇均低于常规组(P<0.05),研究组SAS、SDS评分低于常规组(P<0.05),研究组血清皮质醇水平低于常规组(P<0.05)。结论对于2型糖尿病伴发抑郁症患者在常规治疗基础上加用帕罗西汀,不仅可以减轻其负面情绪,改善患者血糖、血脂,而且还可以降低其血清皮质醇水平。
Objective To study the clinical efficacy of paroxetine in the treatment of type 2 diabetic patients with depression. Methods From December 2018 to December 2019,98 type 2 diabetes mellitus patients with depression were selected and divided into the routine group and the study group,49 cases in each group. The patients in routine group received routine treatment,while in study group received paroxetine on the basis of routine treatment. Results The clinical effect of the study group was higher than that of the routine group(P<0.05). The fasting blood glucose,2-hour postprandial blood glucose,glycosylated hemoglobin,triacylglycerol and total cholesterol of the study group were lower than those of the routine group(P<0.05). The SAS and SDS scores of the study group were lower than those of the routine group(P<0.05). The serum cortisol level of the study group was lower than that of the routine group(P<0.05). Conclusion For type 2 diabetes mellitus patients accompanied with depression,the paroxetine can not only improve blood glucose and blood lipid,reduce their negative emotions,but also reduce the level of serum cortisol.
作者
杨洁
杨亚平
柴朵
YANG Jie;YANG Yaping;CHAI Duo(Zhumadian Central Hospital,Zhumadian 463000,China)
出处
《国际精神病学杂志》
2020年第6期1187-1189,共3页
Journal Of International Psychiatry
关键词
帕罗西汀
2型糖尿病
抑郁症
临床疗效
Paroxetine
Type 2 diabetes mellitus
Depression
Clinical efficacy
作者简介
第一作者/通讯作者:杨洁(1977.12-),女,河南驻马店人,本科,住院医师,研究方向:(内科)内分泌代谢疾病,Email:yp8gwa@163.com。
