摘要
目的观察腹膜透析(peritoneal dialysis, PD)患者微炎症状态及其相关因素,并探讨其对主动脉弓钙化的影响。方法对就诊于武汉大学人民医院的153例PD患者的临床资料行回顾性分析,采用胸部X线片评估主动脉弓钙化情况。根据是否合并主动脉弓钙化分为无钙化组(n=111)及钙化组(n=42),比较两组基本信息和生化指标,用Logistic回归分析主动脉弓钙化的独立危险因素。再根据患者超敏C反应蛋白(high sensitivity C-reactive protein, hsCRP)水平分为正常组(n=94)和微炎症组(n=59),比较两组临床指标。结果 153例患者主动脉弓钙化发生率为27.45%(42/153),钙化组hsCRP明显高于无钙化组,Logistic回归分析结果显示,年龄、hsCRP为主动脉弓钙化的独立危险因素。伴随微炎症状态者占38.56%(59/153),微炎症组主动脉弓钙化比例较高(37.29%vs 21.27%,P<0.05),相关分析表明,hsCRP与主动脉弓钙化呈正相关,Logistic回归分析结果显示年龄、血小板为hsCRP升高的独立危险因素。结论腹膜透析患者微炎症状态及主动脉弓钙化发生率较高,微炎症是主动脉弓钙化的危险因素,监测并改善PD患者微炎症状态可能有助于减少主动脉弓钙化的发生。
Objective To observe the microinflammation state and its related factors,and to explore its effect on aortic arch calcification in peritoneal dialysis(PD)patients.Methods The clinical data of 153 PD patients in Renmin′s Hospital of Wuhan University were retrospectively analyzed.The aortic arch calcification state was evaluated by chest X-ray.According to the presence or absence of aortic arch calcification,the patients were divided into two groups:non calcification group(n=111)and calcification group(n=42).According to the level of high sensitivity C-reactive protein(hsCRP),the patients were divided into normal group(n=94)and microinflammation group(n=59).The clinical data of the two groups were compared.Results The incidence of aortic arch calcification was 27.45%(42/153).HsCRP in calcification group was significantly higher than that in non-calcification group.Logistic regression analysis shows that age and hsCRP were independent risk factors for aortic arch calcification.38.56%(59/153)of the patients were accompanied with microinflammation state.The proportion of aortic arch calcification was higher in microinflammation group(37.29%vs 21.27%,P<0.05).Correlation analysis showed that hsCRP was positively correlated with aortic arch calcification,Logistic regression analysis shows that age and platelets were independent risk factors for hsCRP.Conclusion The incidence of microinflammation and aortic arch calcification is higher in peritoneal dialysis patients.Microinflammation is a risk factor for aortic arch calcification.Monitoring and improving the microinflammation state of PD patients may help to reduce the occurrence of aortic arch calcification.
作者
李艺
丁国华
Li Yi;Ding Guohua(Department of Nephrology,Renmin Hospital of Wuhan University,Hubei 430060,China)
出处
《医学研究杂志》
2021年第2期37-42,共6页
Journal of Medical Research
基金
国家自然科学基金资助项目(81770687)。
关键词
腹膜透析
血管钙化
主动脉弓钙化
微炎症
Peritoneal dialysis
Vascular calcification
Aortic arch calcification
Microinflammation
作者简介
通讯作者:丁国华,电子信箱:ghxding@qq.com。
