摘要
目的:研究青年(≤35岁)胃癌患者的临床病理特征和预后的影响因素。方法:回顾性收集湖南省肿瘤医院2010年10月至2017年12月行根治性切除的2029例Ⅰ-Ⅲ期胃癌患者的临床病理资料,根据患者首次确诊时年龄大小分为青年组(n=75)和对照组(n=1954)。对比两组患者的一般状况、病理结果和长期生存等,采用χ^(2)或t检验分别对比分析分类变量和连续变量,Kaplan-Meier法、Log-rank检验及Cox回归多因素分析预后影响因素。结果:青年组胃癌患者的平均年龄为30.13岁(19~35)岁,其中53.3%为女性。与对照组相比,青年组患者中女性患者的比例更高,术前白蛋白水平更高,全身合并症的发生率及术后并发症的发生率更低,术后住院时间更短,而接受新辅助化疗和辅助化疗的比例更高(均P<0.05)。青年组和对照组术后1、3和5年生存率没有统计学差异(94.6%、60.1%、54.2%vs 89.3%、67.7%、58.1%,P=0.601)。进一步Cox回归多因素分析显示,肿瘤病理分期是影响青年胃癌患者术后生存的主要因素。结论:青年胃癌患者以女性更为常见,早期发现,行根治性切除以后,接受辅助化疗等治疗,其预后与中老年患者相当。
Objective:To investigate the clinicopathological features and prognosis of gastric cancer(GC)in young patients(≤35 years old).Methods:The clinicopathological data of 75 young patients(≤35 years old)and 1954 older patients(>35 years old,control group)undergoing radical gastrectomy for stageⅠ-ⅢGC in Hunan Cancer Hospital from October 2010 to December 2017 were retrospectively reviewed.The difference of demographic characteristics,pathological results and long term survival between the two groups were compared byχ^(2) or t test(for categorical or continuous variables),or Kaplan-Meier method,Log-rank test and Cox proportional hazard regression analysis(for prognosis).Results:The mean age of the 75 young patients was 30.13(19~35)years old,with a slight female predominance(53.3%).Compared with the older patients,young GC patients had a higher rate of female,higher pre-operative albumin level,lower proportions of comorbidities and post-operative complications,shorter post-operative hospital stays,but more likelihood of receiving neo-adjuvant and adjuvant chemotherapy(all P<0.05).The 1-,3-and 5-year survival rates of the young patients were 94.6%,60.1%and 54.2%,which were comparable with those in the control group(89.3%,67.7%and 58.1%,P=0.601).Further analysis showed that pathological tumor stage was the main risk factor for prognosis of the young GC patients.Conclusion:GC in young patients trends to be female predominant.Given early detection,receiving radical gastrectomy and adjuvant chemotherapy,the prognosis of young GC patients is comparable with that in older patients.
作者
肖艳平
肖华
XIAO Yanping;XIAO Hua(Changsha Health Vocational College,Hunan Changsha 410010,China;Department of Gastrointestinal Surgery,Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Hunan Changsha 410013,China)
出处
《现代肿瘤医学》
CAS
北大核心
2021年第6期998-1001,共4页
Journal of Modern Oncology
基金
湖南省自然科学基金青年基金项目(编号:2020JJ5339)
湖南省卫生健康委2020年度科研课题(编号:20200608)
长沙市科技计划项目(编号:kq1907125)。
关键词
胃癌
胃切除
年龄
预后
gastric cancer
gastrectomy
age
prognosis
作者简介
肖艳平(1985-),女,湖南邵阳人,主治医师,硕士,主要从事消化道肿瘤的临床及基础研究。E-mail:44135478@qq.com;通讯作者:肖华(1984-),男,湖南邵阳人,副主任医师,博士,主要从事消化道肿瘤的临床及基础研究。E-mail:huakexh2010@163.com。
