摘要
目的:观察用维持性血液透析联合中药保留灌肠法治疗尿毒症对患者体内中小分子毒素水平的影响。方法:选择2019年1月至12月在龙泉市人民医院血液净化中心接受维持性血液透析(透析的时间在6个月以上)的尿毒症患者100例,将其随机分为观察组和对照组(50例/组)。对观察组患者进行维持性血液透析联合中药保留灌肠治疗,对对照组患者进行单纯维持性血液透析治疗。治疗8周后,对比两组患者血肌酐(SCr)、血尿素氮(BUN)、血清钾(K)、磷(P)、甲状旁腺激素(iPTH)、β_(2)微球蛋白的水平。结果:1)在对观察组患者进行中药保留灌肠治疗前,其SCr、BUN、血清K、P、iPTH、β_(2)微球蛋白的水平与同期对照组患者SCr、BUN、血清K、P、iPTH、β_(2)微球蛋白的水平相比,P>0.05。2)接受中药保留灌肠治疗后,观察组患者SCr、BUN、血清K、P、iPTH的水平均较治疗前显著降低,P<0.05;其血清β_(2)微球蛋白的水平与治疗前相比,P>0.05。3)在对观察组患者进行中药保留灌肠治疗后,其SCr、BUN、血清K、P的水平均低于同期对照组患者SCr、BUN、血清K、P的水平,P<0.05;其血清iPTH、β_(2)微球蛋白的水平与同期对照组患者血清iPTH、β_(2)微球蛋白的水平相比,P>0.05。结论:进行维持性血液透析联合中药保留灌肠在清除尿毒症患者体内小分子毒素(SCr、BUN、血清K、P)方面的效果要优于维持性血液透析,在清除其体内中分子毒素血清iPTH方面的效果可能优于维持性血液透析,在清除其体内中分子毒素血清β_(2)微球蛋白方面的效果与维持性血液透析相近。
Objective:To observe the effect of maintenance hemodialysis combined with traditional Chinese medicine retention enema in the treatment of uremia on the levels of small and medium-sized molecular toxins in patients.METHODS:A total of 100 patients with uremia who received maintenance hemodialysis(dialysis duration over 6 months)in Blood Purification Center of Longquan People’s Hospital from January to December 2019 were selected and randomly divided into observation group and control group(50 cases/group).The observation group was treated with maintenance hemodialysis combined with traditional Chinese medicine retention enema,and the control group was treated with maintenance hemodialysis alone.After 8 weeks of treatment,the levels of serum creatinine(SCR),blood urea nitrogen(BUN),serum potassium(K),phosphorus(P),parathyroid hormone(iPTH)andβ_(2) microglobulin in 2 groups were compared.RESULTS:1)The levels of SCR,BUN,K,P,iPTH andβ_(2) microglobulin in observation group were compared with those in control group before traditional Chinese medicine retention enema treatment,P>0.05.2)After traditional Chinese medicine retention enema treatment,the levels of Scr,BUN,serum K,P and iPTH in observation group were significantly decreased compared with before treatment,P<0.05;The level of serumβ_(2) microglobulin was P>0.05 compared with that before treatment.3)After traditional Chinese medicine retention enema treatment,the levels of SCR,BUN,serum K and P in observation group were all lower than those in control group(P<0.05);The levels of IPTH andβ_(2) microglobulin in serum were compared with those in control group(P>0.05).Conclusion:in maintenance hemodialysis combined Chinese medicine retain enema in uremia patients with small molecules in the body of toxins(SCr,BUN,serum K,P)is superior to the effect of maintenance hemodialysis,in terms of clearing the molecules in the toxin inside body serum iPTH may be superior to the effect of maintenance hemodialysis,in its molecules in the toxin inside body serum beta 2 microglobulin effect similar to maintenance hemodialysis.
作者
潘永金
吴峰芬
蒋良炎
金少芬
兰小红
PAN Yongjin;WU Fengfen;JIANG Liangyan;JIN Shaofen;LAN Xiaohong(Department of Nephrology,Longquan People’s Hospital,Lishui 323700)
基金
龙泉市重点科技计划项目(2019-2021)。
关键词
中药保留灌肠
维持性血液透析
中分子
小分子
毒素
traditional Chinese medicine retention enema
Maintenance hemodialysis
The molecules of
Small molecules
poison
作者简介
潘永金(1987-),男,汉族,浙江龙泉人,医学学士,主治中医师,丽水市中西医结合学会肾脏病专业委员会委员,研究方向:中西医结合治疗肾病及经典中医临床研究,E-mail:446045562@qq.com;通讯作者:吴峰芬。
