摘要
目的:分析基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)在成釉细胞瘤中的表达,比较其在成釉细胞瘤各病理类型间的差异及与侵袭性的关系。方法:收集2005—2009年于北京大学口腔医院手术所得成釉细胞瘤石蜡标本26块,对标本进行免疫组织化学(免疫组化)染色。MMP-2为一抗,在高倍镜下观察,因细胞较少,深褐色区域>50%为强阳性,26%~50%为中等阳性,5%~25%或仅有少量斑点为弱阳性,<5%为阴性。数据处理采用χ2检验。结果:MMP-2表达总阳性率为88.5%,强阳性率为65.4%,阴性率为3.8%。在肿瘤外周柱状细胞、基质细胞等细胞内均可见MMP-2的表达。结论:MMP-2与成釉细胞瘤的局部侵袭性相关,各病理类型间MMP-2表达无显著差异。
Objective:To investigate matrix metalloproteinase-2(MMP-2)expression of ameloblastoma within different pathological types and discuss its relation to invasive behaviors.Methods:A total of 26 ameloblastoma specimens acquired from Peking University Hospital of Stomatology were analyzed immunohistochemically with a specific marker of MMP-2 and graded in which dark brown areas>50%were strongly positive,26%-50%were moderately positive,5%-25%or only a few spots were weakly positive,and<5%were negative.Data processing adoptedχ2 test.Results:The total positive rate of MMP-2 expression was 88.5%,the strongly positive rate was 65.4%,and the negative rate was 3.8%.MMP-2 expression can be seen in tumor peripheral columnar cells,stromal cells and other cells.Conclusion:MMP-2 is related to the local invasiveness of ameloblastoma,and there is no significant difference in the expression of MMP-2 among various pathological types.
作者
陆长玺
郭传瑸
LU Changxi;GUO Chuanbin(Department of General Dentistry,Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology,Shanghai 200011;Department of Oral and Maxillofacial Surgery,School and Hospital of Stomatology,Peking University,Beijing 100081,China)
出处
《口腔颌面外科杂志》
CAS
2021年第1期28-31,共4页
Journal of Oral and Maxillofacial Surgery
作者简介
陆长玺(1983-),男,江苏江阴人,主治医师,博士.E-mail:changxilu@163.com;通信作者:郭传瑸,教授.E-mail:guodazuo@sina.com。
