摘要
目的研究多囊卵巢综合征(PCOS)不孕症患者不同促排卵方案的治疗效果。方法收集2018年1月至2020年1月来我院行促排卵治疗的120例PCOS排卵障碍不孕症患者,随机分配至不同促排卵方案治疗组:克罗米芬组(n=40)、来曲唑组(n=40)、尿促性素组(n=40)。统计分析3组患者的促排卵效果及妊娠结局。结果与克罗米芬组、来曲唑组比较,尿促性素组患者的用药周期少、促排卵天数短、HCG日子宫内膜厚、成熟卵泡数量多,差异均有统计学意义(P<0.05),但3组患者间最大卵泡直径差异无统计学意义(P>0.05);克罗米芬组与来曲唑组患者的用药周期数、促排卵天数、HCG日子宫内膜厚度、成熟卵泡数量均无显著性差异(P>0.05)。尿促性素组患者的排卵率、临床妊娠率均显著高于克罗米芬组、来曲唑组(P<0.05),而早期流产率显著低于克罗米芬组、来曲唑组(P<0.05),但3组患者间卵巢过度刺激综合征发生率、多胎妊娠率、异位妊娠率均无显著性差异(P>0.05);克罗米芬组与来曲唑组患者的排卵率、临床妊娠率、早期流产率均无显著性差异(P>0.05)。结论PCOS不孕症患者采用尿促性素促排卵的治疗效果较克罗米芬、来曲唑好,但其推广较口服药物难度大,需要临床依据实际情况合理选择。
Objective:To study the therapeutic effects of different ovulation induction protocols on infertile patients with polycystic ovary syndrome(PCOS).Methods:A total of 120 infertility patients with PCOS were recruited in our hospital from January 2018 to January 2020.According to the ovulation induction protocol,they were divided into three groups:clomiphene group(n=40),letrozole group(n=40),and urogonadotropin group(n=40).The ovulation induction effect and pregnancy outcome of the three groups were statistically analyzed.Results:Compared with the clomiphene group and the letrozole group,the medication cycle and the days of induction ovulation of the urogonadotropin group were significantly shorter;the endometrial thickness on the day of HCG injection was significantly thicker;and the number of mature follicles was significantly more(all P<0.05).However,the maximum follicle diameter was not significantly different among the three groups(P>0.05).There were no significant differences in medication cycle,the days of induction ovulation,the thickness of the endometrium on the day of HCG injection,and the number of mature follicles between the clomiphene and letrozole group(P>0.05).The ovulation rate and clinical pregnancy rate in the urogonadotropin group were significantly higher and the early abortion rate was significantly lower than those of the clomiphene group and letrozole group(P<0.05).There were no significant differences in the incidence of ovarian hyperstimulation syndrome(OHSS),multiple pregnancy rate,and ectopic pregnancy rate among the three groups(P>0.05).The ovulation rate,clinical pregnancy rate and early abortion rate of patients were not significant different between the clomiphene group and letrozole group(P>0.05).Conclusions:The therapeutic effect of urogonadotropin is better than that of clomiphene and letrozole in infertile patients with PCOS.However,its promotion is more difficult than oral drugs,so it needs to be selected reasonably according to the actual situation.
作者
覃晓
黎枝
覃卫玲
庞海燕
黄丽棉
QIN Xiao;LI Zhi;QIN Wei-ling;PANG Hai-yan;HUANG Li-mian(Reproductive Medicine Center,People’s Hospital of Baise City,Baise 533000)
出处
《生殖医学杂志》
CAS
2021年第2期175-178,共4页
Journal of Reproductive Medicine
基金
广西高校中青年教师科研基础能力提升项目(2019KY0573)。
关键词
多囊卵巢综合征
不孕症
促排卵方案
促排卵效果
妊娠结局
Polycystic ovary syndrome
Infertility
Ovulation induction protocol
Ovulation stimulation effect
Pregnancy outcome
作者简介
覃晓,女,广西浦北人,硕士,副主任医师,妇产科生殖内分泌专业;通讯作者:黎枝,Email17846132@qq.com。
