摘要
免疫功能障碍是脓毒症迁延不愈,病死率高的重要原因之一。发生脓毒症时固有免疫与获得性免疫系统均发生改变,但以T细胞为主的获得性免疫系统在脓毒症晚期发挥关键性作用。T细胞凋亡,耗竭及功能下降均可造成免疫抑制状态,引起脓毒症死亡风险增高。本综述以脓毒症早期与晚期免疫状态的比较为切入点,深入阐述导致脓毒症获得性免疫功能障碍的病理生理学机制,包括T细胞凋亡,T细胞耗竭及调节性T细胞功能障碍等。介绍目前针对T细胞免疫调节治疗的新进展,以期深入理解脓毒症免疫功能障碍的机制,并寻求免疫治疗的新靶点。
Immune dysfunction contributes to the development of sepsis and the high mortality of sepsis.Both innate and adaptive immune system has changed during sepsis.Nonetheless,the adaptive immune dysfunction induced by T cells plays a crucial role in the late phase of sepsis.The apoptosis,exhaustion and malfunction of T cells contributes to immune-suppressive status,which leads to high risk for death from sepsis.The review focuses on the immune status and function in the early and late phase of sepsis and states the pathophysiological mechanism of adaptive immune dysfunction in sepsis,including T cell apoptosis,T cell exhaustion and dysfunction of regulatory T cells.Further,it introduces the up-to-date T cells immune therapeutics to better understand the immune dysfunction mechanism during the development of sepsis and to pursue the new target of immune therapy.
作者
孙旖旎
马晓春
Sun Yini;Ma Xiaochun(Department of Critical Care Medicine,the First Affiliated Hospital of China Medical University,Shenyang 110000,China)
出处
《中华重症医学电子杂志》
2020年第4期448-452,共5页
Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)
作者简介
通信作者:马晓春,Email:maxc_cmu@sina.com。
