摘要
尽管近年来重症感染相关的诊疗技术不断提高,老年重症感染患者发病率高、临床表现不典型、预后差、病死率高,需予以重点关注。由于老年患者机体免疫系统功能下降,即免疫衰老,其对重症感染的免疫反应尤为特殊,固有和适应性免疫系统中各免疫细胞数量改变、亚群失衡、功能障碍,免疫失衡更加明显。因此,准确检测老年重症感染患者免疫失衡的动态变化,明确其潜在机制,在此基础上适时应用免疫联合靶向治疗进行有效干预,对于老年重症感染患者的治疗及疾病转归具有重大临床意义。
Although the diagnosis and treatment of severe infections have been constantly improved in recent years,many elderly patients suffered from severe infections with high incidence,atypical clinical manifestations,poor prognosis,and high mortality,which requires a greater emphasis. Because of immunosenescence,a decline in normal immune system function associated with physiological aging,the immune response to severe in fections is particularly special in elderly patients. The immune imbalance is much more obvious in elderly patients with severe infections due to the number alterations of immune cells,subgroup imbalance,and persistent dysfunction in both the innate and adaptive immune systems. Therefore,it is of great significance for improving the prognosis of elderly patients with severe infections to detect the dynamic changes of immune imbalance accurately,identify the underlying mechanisms,and apply appropriate combined immune modulatory therapies targeting immune cells.
作者
何婉雪
解立新
HE Wan-xue;XIE Li-xin(College of Pulmonary and Critical Care Medicine,Chinese PLA General Hospital,Beijing 100853,China)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2020年第12期1005-1009,共5页
Chinese Journal of Practical Internal Medicine
基金
军队重点课题(BLB18J008,A3704041902-03)。
关键词
免疫衰老
重症感染
免疫细胞
功能障碍
immunosenescence
severe infections
immune cells
dysfunction
作者简介
通信作者:解立新,教授、主任医师、博士生导师,中国人民解放军总医院呼吸与危重症医学部主任,兼任中华医学会呼吸病分会全国委员兼呼吸治疗学组组长,危重症学组顾问,中国感染病专业委员会常委兼秘书长,中国康复医学会呼吸康复专业委员会、中国医师协会急救与灾难专业委员会、中国呼吸医师协会危重症专业委员会、中国呼吸医学装备分会副主委。电子信箱:xielx301@126.com。
