摘要
目的探讨疏风解毒胶囊联合特布他林治疗急性小儿支气管炎的疗效及对IL-4、PCT、hs-CRP水平影响。方法选取来安阳市肿瘤医院接受治疗的120例急性小儿支气管炎患儿,随机分为两组,各60例。对照组给予雾化吸入硫酸特布他林雾化液,实验组在对照组基础上口服疏风解毒胶囊,两组均持续治疗14 d。对比两组患儿的临床疗效、临床症状缓解时间和不良反应。对比两组患儿治疗前后临床症状评分、肺功能指标、免疫功能指标及IFN-γ、IL-4、PCT、hs-CRP水平变化。结果治疗后,实验组总有效率较高(P<0.05);经过治疗后,对照组痊愈10例,显效16例,有效24例,无效10例,治疗有效率为83.33%(50/60);实验组12例痊愈,19例显效,26例有效,3例无效,治疗有效率为95.00%(57/60);实验组治疗有效率显著较高(P<0.05);实验组患儿症状缓解时间显著较低(P<0.05);两组治疗后IL-4、PCT、hs-CRP水平显明显降低,IFN-γ水平明显升高(P<0.05);并且实验组IL-4、PCT、hs-CRP水平低于对照组,IFN-γ水平明显高于对照组(P<0.05);两组患儿FEV1、FVC和FEV1/FVC水平显著升高(P<0.05);并且实验组升高较多(P<0.05);两组治疗后CD+4、CD+4/CD+8水平显著降低, CD+8水平显著升高(P<0.05);并且实验组改善较多(P<0.05);两组喘息、咳嗽、发热、肺部罗音评分显著降低(P<0.05);并且实验组降低程度较大(P<0.05);对照组震颤1例,头痛1例,心悸1例,总发生率为5.00%;两组治疗后喘息、咳嗽、发热、肺部罗音评分显著降低(P<0.05);并且实验组降低程度较大(P<0.05);实验组震颤1例,头痛2例,皮疹1例,总发生率为6.67%;两组不良反应发生率无差异(P>0.05)。结论急性小儿支气管炎采用疏风解毒胶囊联合特布他林进行治疗,具有较好的临床疗,能够改善患儿心肺功能,值得在临床上推广应用。
Objective To investigate the effect of Shufeng Jiedu Capsule combined with terbutaline on the levels of IL-4, PCT and hs-crp in the treatment of children with acute bronchitis. Methods A total of 120 children with acute bronchitis were selected and randomly divided into two groups with 60 cases in each. The children in the control group were given atomized inhalation of terbutaline sulfate spray, and those in the experimental group were given oral administration of Shufeng Jiedu Capsule on the basis of the control group. The children in both groups were treated continuously for 14 days. The clinical efficacy, clinical symptom remission time and adverse reactions of the two groups were compared. The changes of lung function index, immune function index, IFN-γ, IL-4, PCT and hs-CRP before and after treatment were compared between the two groups. Results After treatment, the total effective rate of the experimental group was higher(P<0.05). After treatment, 10 cases in the control group recovered, 16 cases showed significant effect, 24 cases were effective, 10 cases were ineffective, and the effective rate was 83.33%(50/60). In the experimental group, 12 cases recovered, 19 cases showed obvious effect, 26 cases were effective, 3 cases were invalid, and the effective rate was 95.00%(57/60). The effective rate in the experimental group was significantly higher(P<0.05). The time of symptom relief in the experimental group was significantly lower(P<0.05). After treatment, levels of IL-4, PCT and hs-CRP were significantly decreased and IFN-γ increased in both groups(P<0.05). In addition, levels of IL-4, PCT and hs-CRP in the experimental group were lower than those in the control group, and IFN-γ level was significantly higher than those in the control group(P<0.05). The levels of FEV1, FVC and FEV1/FVC in the two groups were significantly increased after treatment(P<0.05). In addition, there was a significant increase in the experimental group(P<0.05). After treatment, the levels of CD+4 and CD+4/CD+8 in the two groups were significantly decreased, and the level of CD+8 was significantly increased(P<0.05). The experimental group showed more improvement(P<0.05). The rales scores of wheezing, coughing, fever and lung in both groups were significantly decreased(P<0.05). And those of the experimental group decreased significantly(P<0.05). In the control group, 1 patient had tremor, 1 patient had headache and 1 patient had palpitation, with a total incidence of 5.00%. In the experimental group, 1 patient had tremor, 2 patients had headache and 1 patient had rash, with a total incidence of 6.67%. Conclusion Shufeng Jiedu Capsule combined with terbutaline has a good clinical effect on acute pediatric bronchitis and can improve the cardiopulmonary function of children, worthy of clinical application.
作者
赵丽洁
赵慧
智玲玲
秦芳
ZHAO Lijie;ZHAO Hui;ZHI Lingling;QIN Fang(School of Medicine and Health,Anyang Vocational and Technical College,Anyang 455000,Henan,China;Anyang Tumor Hospital,Anyang 455000,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第12期183-186,共4页
Chinese Archives of Traditional Chinese Medicine
基金
河南省中医药科学研究专项(2015ZY02035)。
作者简介
赵丽洁(1968-),女,河南安阳人,副教授、副主任医师,硕士,研究方向:妇儿临床;通讯作者:赵慧(1986-),女,河南安阳人,讲师,学士,研究方向:呼吸内科。
