摘要
目的:探讨老年持续性心房颤动患者血清晚期糖基化终产物羧甲基赖氨酸(CML)、超氧化物歧化酶(SOD)、肿瘤坏死因子-α(TNF-α)的水平变化,并探讨其临床意义。方法:选择老年心房颤动患者50例(年龄≥65岁),对照组为同期住院的年龄≥65岁非心房颤动患者30例。用ELISA法检测血CML、SOD、TNF-α的水平。彩色多普勒超声检测左心室射血分数(LVEF)、左心房内径。结果:与对照组相比,老年心房颤动组血清CML、TNF-α均明显升高(均P<0.05),血清SOD较对照组降低(P<0.05),LVEF和左心房内径亦较对照组显著升高(均P<0.05)。结论:晚期糖基化终末产物是促使老年心房颤动发生的一种重要生物物质,有可能通过氧化应激参与了房颤的病理生理过程。
Objective:To investigate the changes in serum levels of advanced glycation end products carboxymethyllysine(CML),superoxide dismutase(SOD)and tumor necrosis factor-α(TNF-α)in elderly patients with persistent atrial fibrillation,and to explore its clinical significance.Methods:50 elderly patients with atrial fibrillation(age≥65 years)were selected as the elderly atrial fibrillation group,and and 30 non-atrial fibrillation patients aged≥65 years who were hospitalized during the same period were selected as the control group.The levels of serum CML,SOD,and TNF-αwere detected by ELISA.Color Doppler ultrasound was used to detect LVEF and left atrium inner diameter.Results:Compared with the control group,the serum CML and TNF-αof the elderly atrial fibrillation group were significantly increased(all P<0.05),and the serum SOD was lower(P<0.05),and the LVEF and left atrial diameter were higher(all P<0.05).Conclusion:The advanced glycation end products are an important biological substance that promotes the occurrence of elderly atrial fibrillation,and may participate in the pathophysiological process of atrial fibrillation through oxidative stress.
作者
李莹
纪玉强
蔡琴
李晨辉
LI Ying;JI Yuqiang;CAI Qin;LI Chenghui(Department of Cardiology,Xi’an No.1 Hospital,Xi’an 710002,China)
出处
《陕西医学杂志》
CAS
2021年第1期29-31,共3页
Shaanxi Medical Journal
基金
陕西省重点研发计划项目(2018SF-130)
西安市科技计划项目[201805094YX2SF28(8)]。
关键词
晚期糖基化终末产物
羧甲基赖氨酸
心房颤动
老年
氧化应激
炎性因子
Advanced glycation end products
Carboxymethyllsine
Atrial fibrillation
Aging
Oxidative stress
Inflammation factor
