摘要
SIRT1属于沉默信息调节因子家族成员,具有去乙酰化酶活性,在阿尔茨海默病中发挥重要保护作用。氧化应激是阿尔茨海默病的发病机制之一,当前研究已发现,SIRT1可通过Aβ、PGC1-α、FOXO3a、Nrf2、p53影响ROS产生、抗氧化酶活性、神经元存活状态,从而调节大脑氧化应激损伤,但其机制尚未阐明。该文通过综述国内外最新研究进展,深入探讨SIRT1对阿尔茨海默病氧化应激的调控机制,将为SIRT1作为阿尔茨海默病的治疗标靶提供依据和方向。
SIRT1,a member of the silencing information regulator family,has deacetylase activity and plays an important protective role in Alzheimer’s disease.Oxidative stress is one of the pathogenesis mechanisms of Alzheimer’s disease.Current studies have found that SIRT1 can affect ROS production,antioxidant enzyme activity and neuron death through Aβ,PGC1-α,FOXO3a,Nrf2,and p53,thus regulating brain oxidative stress injury,but its mechanism still needs to be clarified.In this paper,the latest research progress at home and abroad is reviewed to further explore the regulation mechanism of SIRT1 on oxidative stress in Alzheimer’s disease,which will provide the basis and direction for SIRT1 as a target for the treatment of Alzheimer’s disease.
作者
王文家
娄淑杰
WANG Wenjia;LOU Shujie(Institute of Sports Science,Shanghai University of Sport,Shanghai 200438,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2020年第11期2038-2044,共7页
Chinese Journal of Cell Biology
基金
上海市人类运动能力开发与保障重点实验室(上海体育学院)(批准号:11DZ2261100)资助的课题。
作者简介
通讯作者:娄淑杰,Tel:021-51253243,E-mail:shujielou319@163.com。
