摘要
目的:研究连钱草正丁醇部位的化学成分。方法:采用多种柱色谱分离方法和液相色谱分离方法对连钱草正丁醇部位进行分离纯化,根据化合物的理化性质以及波谱数据鉴定化合物结构。结果:从连钱草正丁醇部位分离得到6个化合物,分别鉴定为:①丁香脂素-O-β-D-葡萄糖苷;②芹菜素-7-O-β-D-芹糖(1→2)-β-D-葡萄糖苷;③Shimobashiric acid C;④(+)-异落叶松脂素9′-O-β-葡萄糖苷;⑤(7S,8R)dehydrodiconiferyl alcohol 9′-β-glucopyranoside;⑥3-(3,4-dihydroxyphenyl)-acrylic acid 1-(3,4-dihydroxyphenyl)-2-methox-ycarbonylethyl ester。结论:以上化合物均为首次从连钱草中分离得到。
Objective:To study the chemical constituents of Glechoma Longituba.Methods:Various methods including column chromatography and HPLC were used to isolate andpurify the compounds of n-butanol extract part of the Glechoma longituba.The chemical structures were identified on basis of physic-chemical properties and spectral data.Results:6 compounds were isolated from the n-butanol extract of Glechoma Longituba,and identifi-ed as 1.syringaresinol-O-β-D-glucopyranoside;2.apigenin-7-O-β-D-api-ofuranosyl(1→2)-β-D-glucopyranoside;3.Shimobashiric acid C;4.(+)-isolariciresinol-9′-O-β-glucopyranoside;5.(7S,8R)dehydrodiconiferyl alcohol 9′-β-glucopyranoside;6.3-(3,4-dihydroxyphenyl)-acrylic acid 1-(3,4-dihydroxyphenyl)-2-Methoxycarbonylethyl ester.Conclusion:All compounds areisolated from this plant for the first time.
作者
熊晓丽
吴西
袁铭铭
钟瑞建
XIONG Xiaoli;WU Xi;YUAN Mingming;ZHONG Ruijian(Jiangxi Provincial Institute for Drug Control,NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality,Nanchang Jiangxi 330029,China;Jiangxi University of Traditional Chinese Medicine,Nanchang Jiangxi 330004,China)
出处
《药品评价》
CAS
2020年第19期13-15,21,共4页
Drug Evaluation
基金
江西省重点研发计划项目(20171BBG70104)。
关键词
连钱草
化学成分
结构鉴定
Glechoma Longituba
Chemical Composition
Structure Identification
作者简介
熊晓丽,在读硕士。研究方向:中药活性成分及质量标准研究。E-mail:1150859907@qq.com;通信作者:钟瑞建,本科,主任中药师。专业方向:药物分析。E-mail:zhongrj@jxfda.gov.cn。
