摘要
目的分析参附注射液在院外急救改善急性左心衰的效果。方法选择2018年11月—2019年11月北京急救中心急救的急性左心衰(acute left heart failure,ALHF)患者124例,采用随机分为两组,每组62例。对照组采用常规急救措施治疗,观察组在对照组基础上给予参附注射液治疗。分析两组患者从院外接诊患者到送达同一家医院急诊之前时间段T1,送达医院后在急诊室1h内完成相关检查时间段T2,随后住院进一步治疗,入院3 d再次检查的时间段T3的临床生命体征(心率、血压)、血氧饱和度(pulse oxygen saturation,SpO2)、B型利钠肽前体(B-type pro-brain natriuretic peptide,pro-BNP)以及C反应蛋白(C-reactive protein,CRP)指标变化。结果在时间段T1,两组患者的心率、血压(收缩压、舒张压)、SpO2比较无明显差异(P>0.05);在时间段T2、T3,两组患者的心率、血压均较在时间段T1明显降低,而SpO2水平明显上升(P<0.05),但观察组的心率、血压、SpO2改善水平明显优于对照组(P<0.05)。两组在时间段T3的CRP、pro-BNP水平均较时间点T2的指标明显降低(P<0.05),但观察组的以上指标水平改善明显优于对照组(P<0.05)。观察组平均住院时间短于对照组(P<0.05),而观察组与对照组的病死率(7.14%vs 14.28%)比较,无统计学意义(P>0.05)。结论参附注射液在院外急救可以短时间内改善ALHF患者的心功能、临床生命体征,保障患者的生命安全。
Objective To analyze the effect of Shenfu injection on pre-hospital first aid to improve acute left heart failure.Methods 124 patients with ALHF who received emergency treatment at Beijing emergency center from November 2018 to November 2019 were selected and randomly divided into two groups,with 62 patients in each group.The control group was treated with conventional emergency measures,and the observation group was treated with shenfu injection on the basis of the control group.Analysis of two groups of patients from patients with pre-hospital accepts to reach the same hospital emergency period before T1,reach a hospital in an emergency room after 1 hours to complete the relevant inspection time T2,then further treatment in hospital,hospital 3 days again check time T3 clinical signs of life heart rate,blood pressure,blood oxygen saturation(SpO2),b-type natriuretic peptide precursor(pro-BNP)and c-reactive protein(CRP)index changes.Results At time T1,there were no significant differences in heart rate,blood pressure(systolic blood pressure,diastolic blood pressure)and SpO2 between the two groups(P>0.05).In time period T2 and T3,the heart rate and blood pressure of patients in both groups were significantly lower than that in time period T1,while the level of SpO2 was significantly increased(P<0.05).However,the improvement level of heart rate,blood pressure and SpO2 in the observation group was significantly better than that in the control group(P<0.05).CRP and pro-bnp levels in the two groups at time period T3 were significantly lower than those at time point T2(P<0.05),but the improvement of the above indicators in the observation group was significantly better than that in the control group(P<0.05).The mean length of hospital stay in the observation group was shorter than that in the control group(P<0.05),while the fatality rate between the observation group and the control group(7.14%vs 14.28%)was not statistically significant(P>0.05).Conclusion Shenfu injection can improve the heart function and clinical vital signs of ALHF patients in a short period of time,reduce the levels of pro-BNP and CRP,which ensures the safety of patients.
作者
陈棁
杨旭
郭增勋
CHEN Zhuo;YANG Xu;GUO Zengxun(Beijing Emergency Medical Center Beijing 100031,China)
出处
《中国急救复苏与灾害医学杂志》
2020年第12期1390-1393,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
基金
北京市重点科技计划资助项目(编号:Z191100004419003)。
关键词
急性左心衰
参附注射液
急救
Acute left heart failure
Shenfu injection
first aid
作者简介
通信作者:杨旭,E-mail:yanxixi120@163.com。
