摘要
目的探讨多重耐药病原菌对呼吸机相关性肺炎预后的影响。方法选择2012年1月至2018年6月在上海市肺科医院诊断为VAP的382例患者作为研究对象,观察临床资料与预后的相关性。结果382例VAP患者有172例分离出多重耐药菌。多重耐药和非多重耐药患者性别、年龄、原发肺部疾病、VAP类型、诊断前联合应用抗生素、合并心血管疾病和糖尿病、激素应用情况、28d生存状态等因素均存在差异(P<0.05)。多因素Logistic分析显示,其他菌耐药是导致VAP患者死亡的独立危险因素(P<0.05)。结论非发酵革兰阴性杆菌多重耐药不影响VAP患者的28d生存率,其他菌种耐药,是影响VAP患者28d死亡率的危险因素,值得进一步研究。
Objective To investigate the effect of multi-drug resistant pathogens on the prognosis of ventilator-associated pneumonia.Methods 382 patients with VAP diagnosed in our hospital from January 2012 to June 2018 were selected as the study subjects,and the correlation between clinical data and prognosis was observed.Results 172 multi-drug resistant bacteria were isolated from 382 VAP patients.There were differences in gender,age,primary lung disease,VAP type,pre-diagnostic antibiotics,cardiovascular disease and diabetes,hormonal application,and 28-day survival status in patients with multi-drug and non-multi-drug resistance(P<0.05).Multivariate,logistic analysis showed that only other bacterial resistance was an independent risk factor for death in patients with VAP(P<0.05).Conclusion Multi-drug resistance of non-fermenting Gram-negative bacilli does not affect the 28-day survival rate of patients with VAP.The resistance of other strains is a risk factor affecting the mortality of patients with VAP for 28 days,which is worthy of further study.
作者
毛彦华
MAO Yan-hua(Shanghai Pulmonary Hospital,Shanghai 200433,China)
出处
《临床肺科杂志》
2021年第1期21-24,共4页
Journal of Clinical Pulmonary Medicine
关键词
呼吸机相关性肺炎
多重耐药
预后
ventilator-associated pneumonia
multi-drug resistance
prognosis
