摘要
目的:探讨血清表皮生长因子(EGF)、基质金属蛋白酶抑制剂(TIMPs)的变化与子宫肌瘤发生的关系。方法:选取2017年1月-2018年10月本院妇科收治的110例子宫肌瘤患者为病例组,同期妇科检查未发现子宫内病变的志愿者110例为对照组,比较两组及病例组不同肌瘤大小、肌瘤位置、肌瘤直径患者血清EGF、TIMPs水平差异。结果:病例组血清EGF水平(343.8±82.0 pg/ml)高于对照组,血清TIMP2(226.6±67.1 ng/ml)、TIMP9(165.8±33.0 ng/ml)水平低于对照组(均P<0.05);病例组中,黏膜下肌瘤者血清EGF水平高于肌壁间者,子宫肌瘤多发者血清TIMP2水平低于单发者,子宫肌瘤多发、肌瘤直径>6.0cm患者的TIMP9水平低于肌瘤单发、肿瘤直径≤6.0cm者(均P<0.05)。结论:子宫肌瘤患者血清EGF升高、TIMPs降低,并且与肌瘤的发展变化有一定关系。
Objective:To investigate the relationship between change of serum epidermal growth factor(EGF)and tissue inhibitor of metalloproteinases(TIMPs)levels of women and the occurrence and development of their uterine fibroids.Methods:110 women with uterine fibroids were selected in study group,and 110 healthy women were selected in the control group.The serum EGF and TIMPs levels of women were compared between the two groups.The serum EGF and TIMPs levels were compared between the women with different fibroid size,fibroid position,or fibroid diameter.Results:The serum EGF level of women in the study group was 343.8±82.0 pg/ml,which was significant higher than that of women in the control group(P<0.05).The serum levels of TIMP2 and TIMP9 of women in the study group were 226.6±67.1 ng/ml and 165.8±33.0 ng/ml,which were significant lower than those of women in the control group(P<0.05).In the study group,the serum EGF level of women with submucosal myoma was significant higher than that of women with muscle wall,the serum TIMP2 level of women with multiple uterine fibroids was significant lower than that of women with single uterine fibroid,and the serum TIMP2 level of women with diameter of uterine fibroids>6.0cm was significant lower than that of women with diameter of uterine fibroids≤6.0cm(all P<0.05).Conclusion:The serum EGF level of women with uterine fibroids increases,but the TIMPs level decreases,which all have a certain relationship with the development of uterine fibroids.
作者
赵春锋
赵春晓
杨焕民
ZHAO Chunfeng;ZHAO Chunxiao;YANG Huanmin(Jinan Hospital, Shandong Province, 250014)
出处
《中国计划生育学杂志》
2020年第11期1898-1900,共3页
Chinese Journal of Family Planning
关键词
子宫肌瘤
表皮生长因子
基质金属蛋白酶抑制剂
Uterine fibroids
Epidermal growth factor
Matrix metalloproteinase inhibitor
