摘要
目的探讨良性前列腺增生(BPH)致膀胱出口梗阻(BOO)合并逼尿肌功能减弱(DU)的电切术治疗疗效及对围术期神经生长因子(NGF)水平的影响。方法根据随机双盲法将2017年2月至2019年3月齐河县人民医院诊治的220例BPH致BOO合并DU患者分为研究组(n=110)和对照组(n=110)。研究组采用经尿道等离子前列腺剜除电切术(TUERP)治疗,对照组采用传统经尿道前列腺电切术(TURP)治疗。比较两组患者手术时间、术中出血量等手术相关指标、国际前列腺症状评分(IPSS)和生活质量指数(QOL)、NGF水平表达、勃起功能指数(IIEF-5)以及并发症发生情况。结果研究组患者手术时间、术中出血量、血红蛋白下降值、血钠下降值、膀胱冲洗时间、留置导管时间、住院时间、术后并发症总发生率、逼尿肌中NGF水平表达均比对照组患者低,差异具有统计学意义(P<0.05);术后,研究组患者IPSS、QOL评分均比对照组低,IIEF-5比对照组患者高,差异具有统计学意义(P<0.05)。结论采用TUERP治疗BPH致BOO合并DU的疗效确切,且创伤较小,术后恢复较快,并可加强逼尿肌功能,降低对勃起功能的影响及术后并发症风险,值得临床推广。
Objective To investigate the effect of electrotomy on bladder outlet obstruction(BOO)combined with detrusor underactivity(DU)due to benign prostatic hyperplasia(BPH)and its effect on perioperative nerve growth factor(NGF)level.Methods According to the randomized double blind method,220 patients with BPH to BOO merger DU,treated in Qihe County People′s Hospital from February 2017 to March 2019,were divided into study group(n=110)and the control group(n=110).The study group was treated with transurethral enucleative resection of prostate(TUERP),while the control group with transurethral prostatic electricity cut method(TURP).Operative time,intraoperative blood loss and other operative indicators,international prostate symptom score(IPSS)and quality of life index(QOL),NGF,erectile function index(IIEF-5)and complications were compared between the two groups.Results Operative time,intraoperative blood loss,decreased hemoglobin value,decreased blood sodium value,bladder irrigation time,indwelling catheter time,hospital stay time,total incidence of postoperative complications,and NGF expression in detrusor of patients in the study group were significantly lower than those in the control group(P<0.05).After surgery,IPSS and QOL scores of patients in the study group were lower than those in the control group,and IIEF-5 was higher than those in the control group,with statistically significant differences(P<0.05).Conclusions TUERP has a definite therapeutic effect on BOO combined with DU caused by BPH,with less trauma,faster postoperative recovery,enhanced detrusor function,reduced impact on erectile function and risk of postoperative complications,which is worthy of clinical promotion.
作者
王宗祥
WANG Zongxiang(Department of Urology,Qihe County People's Hospital,Dezhou 251100,Shandong,China)
出处
《中国性科学》
2020年第12期31-35,共5页
Chinese Journal of Human Sexuality
关键词
良性前列腺增生
膀胱出口梗阻
逼尿肌功能减弱
电切术
疗效
神经生长因子水平
Benign prostatic hyperplasia
Bladder outlet obstruction
Detrusor underactivity
Electrotomy
Therapeutic efficacy
Nerve growth factor
作者简介
通讯作者:王宗祥,E-mail:feng727500@163.com。
