摘要
原发性干燥综合征(PSS)是以口干、眼干为突出表现的慢性自身免疫性疾病,病理特征为外分泌腺灶性淋巴细胞浸润,对人体各个器官系统均能造成损害,严重影响患者生活质量。T细胞参与了PSS的发生发展,可能对PSS的早期诊断有重要意义。为探讨T细胞在PSS发病中的作用机制,寻找新的具有高特异性与灵敏性的PSS检测指标,本研究综述T细胞不同亚群在PSS发生机制中的研究进展。
Primary Sjögren’s syndrome(PSS)is a chronic autoimmune disease characterized by dry mouth and dry eyes.The pathological feature is external secretion of adenosine lymphocyte infiltration.It can cause damage to various organ systems of the human body and seriously affect the quality of life of patients.Most studies have shown that T cells participate in the development of PSS,so it may be of great significance for the early diagnosis of PSS.In order to explore the mechanism of T cells in the pathogenesis of PSS and find new PSS detection indexes with high specificity and sensitivity,this paper reviewed the research progress in different T cell subgroups in the mechanism of PSS.
作者
王瑞婷
陈雁飞
汪钰涵
陈卫红
Wang Rui-ting;Chen Yan-fei;Wang Yu-han;Chen Wei-hong(The First School of Clinical Medicine,Lanzhou University,Lanzhou 730000,China;Department of Rheumatology and Immunology,The First Hospital of Lanzhou University,Lanzhou 730000,China)
出处
《兰州大学学报（医学版）》
CAS
2020年第6期45-50,共6页
Journal of Lanzhou University（Medical Sciences）
基金
兰州大学创新创业行动计划基金项目(20190060071)。
作者简介
通信联系人:陈雁飞,女,主任医师,研究方向风湿免疫性疾病,e-mail:chyanfei70@163.com。
