摘要
目的:研究慢性阻塞性肺疾病急性加重(AECOPD)患者在治疗前后血清颗粒蛋白前体(PGRN)的水平变化及对病情评估的临床意义。方法:将AECOPD住院患者97例作为观察组,健康体检者32例作为对照组,分别测定AECOPD患者及对照组治疗前后的血清PGRN水平,记录观察组临床资料并分析与血清PGRN的相关性。结果:AECOPD患者治疗前后血清PGRN水平均高于健康对照组,AECOPD患者治疗后血清PGRN水平较治疗前显著降低,差异具有统计学意义(P<0.05)。AECOPD患者治疗前血清PGRN水平与第1秒用力呼气容积占预计值百分比(FEV1/pred)呈负相关,与COPD评估测试(CAT)评分、C反应蛋白(CRP)、中性粒细胞计数(NEUT)、吸烟状况成正相关,而治疗后血清PGRN水平仍与CAT评分、吸烟状况呈正相关。通过多元线性分析显示FEV1/pred、CRP、CAT评分是与血清PGRN水平的独立影响因素。结论:PGRN可能通过干扰炎症反应参与AECOPD的发病过程,其水平变化对于疾病严重程度及预后评估具有一定临床意义。
Objective:To investigate the changes of serum progranulin(PGRN)levels before and after treatment in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and evaluate its clinical significance.Methods:A total of 97 AECOPD patients were included in this study as observation group and 32 healthy adults were enrolled as the control group.We measured the levels of serum PGRN in the control group and the patients with AECOPD on before and after treatmes and record the clinical data of the observation group,then analyze the correlation with serum PGRN.Results:The serum PGRN level of AECOPD patients before and after treatment was significantly higher than that of the control group.Compared with pretreat ment,the serum PGRN level of AECOPD patients after treatment were significantly decreased and the difference was statistically significant(P<0.05).Correlation analysis indicated that serum PGRN level of AECOPD patients before treatment was negatively correlated with the percentage of forced expiratory volume in the first second(FEV1/pred),and positively correlated with CAT score,C-reactive protein(CRP),neutrophil count(NEUT)and smoking status,and the serum PGRN level of AECOPD patients after treatment was still positively correlated with the CAT score and smoking status.Finally,through multivariate linear regression analysis,statistical results demonstrated FEV1/pred,CRP and CAT score were independent parameters associated with serum PGRN.Conclusion:PGRN may be involved in the pathogenesis of AECOPD by interfering with inflammatory response,and its dynamic changes has clinical significance for the evaluation of disease severity and prognosis.
作者
周利航
王导新(指导)
ZHOU Li-Hang;WANG Dao-Xin(Department of Respiratory and Critical Care Medicine,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2020年第22期2769-2773,共5页
Chinese Journal of Immunology
基金
国家自然科学基金(81670071)资助。
关键词
颗粒蛋白前体
慢性阻塞性肺病
急性加重
炎症
Progranulin
Chronic obstructive pulmonary disease
Acute exacerbation
Inflammation
作者简介
周利航,女,在读硕士,主要从事呼吸道慢性疾病方面的研究,E-mail:zhoulihang666@163.com;通讯作者:王导新,男,博士,主任医师,博士生导师,主要从事急性呼吸窘迫综合征、慢性阻塞性肺疾病方面的研究,E-mail:wangdaoxin1@163.com。
