摘要
迄今为止,脓毒症在医学界仍然是一个难题。研究表明,脓毒症早期促炎和抗炎共同发生,高病死率与后期免疫抑制有关。大量研究显示,程序性死亡受体-1(PD-1)和白细胞介素-35(IL-35)在脓毒症中起着免疫调控的作用,脓毒症发生时PD-1和IL-35的升高可以引起免疫抑制,而通过PD-1和IL-35调节免疫抑制可以降低死亡率。基于此,本文主要对PD-1和IL-35与脓毒症免疫抑制的关系、发生机制以及治疗现状进行综述,以期为脓毒症的诊疗提供理论基础。
So far,sepsis is still a problem in the medical community.Studies have shown that early pro-inflammatory and anti-inflammatory co-occurrence of sepsis,and the high fatality rate is related to late immunosuppression.A large number of studies have shown that programmed death receptor-1(PD-1)and interleukin-35(IL-35)play an immunomodulatory role in sepsis.PD-1 and IL-35 increase can cause immunosuppression,and the regulation of immunosuppression through PD-1 and IL-35 can reduce mortality.Based on this,this article mainly reviews the relationship between PD-1 and IL-35 and the immunosuppression of sepsis,the mechanism and the current status of treatment,in order to provide a theoretical basis for the diagnosis and treatment of sepsis.
作者
周婷
张青青
刘运安
王胜昱
ZHOU Ting;ZHANG Qing-qing;LIU Yun-an;WANG Sheng-yu(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Xi'an Medical University,Xi'an 710077,Shaanxi,China)
出处
《医学信息》
2020年第23期27-30,共4页
Journal of Medical Information
基金
陕西省重点研发计划基金(编号:2017SF-256)
西安市第七批科技计划项目[编号:20YXYJ0001(7)]。
作者简介
周婷(1993.10-),女,陕西西安人,硕士研究生,住院医师,主要从事呼吸与危重症研究;通讯作者:王胜昱(1980.6-),男,陕西西安人,博士,主任医师,副教授,主要从事呼吸与危重症研究。
