摘要
聚己内酯(PCL)是一种生物相容性好、可吸收、易加工改性的聚酯,材料基于PCL纤维的组织工程支架,具有比表面积高、机械性能良好与孔径、孔隙率和纤维取向等结构特征易调控等特点,被广泛应用于组织工程领域。重点综述PCL纤维的组织工程支架的主要应用缺陷(包括细胞亲和力差、降解速度过慢及机械强度低)及改进手段,同时针对基于PCL纤维的组织工程支架在皮肤、血管、神经、肌腱、韧带和软骨等组织再生的最新进展进行归纳总结,发现目前多数研究集中于通过引入生物活性物质或药物以改善细胞-支架相互作用和调控支架降解行为,或通过选取不同的纺丝工艺和参数以改变支架的物理结构,调控支架机械性能与细胞诱导行为。此外,目前多数研究仍停留在实验室阶段,利用基于PCL纤维的组织工程支架低成本、易加工的优势以加快其临床转化是未来重要的发展方向。
Polycaprolactone(PCL)is a kind of biocompatible,absorbable and easily modified polyester.Tissue engineering scaffolds based on PCL fibers are widely used because of their high specific surface area,good mechanical properties,and easy control of pore size,porosity and fiber orientation.In this paper,main application defects of PCL fiber scaffolds,such as poor cell affinity,slow degradation rate and low mechanical strength and the improvement methods were reviewed.At the same time,the latest development of tissue engineering scaffolds based on PCL fiber in the regeneration of skin,blood vessel,nerve,tendon,ligament and cartilage was summarized.It is shown that most of the current studies focused on improving cell-scaffold interaction and regulating the degradation behavior of scaffolds by introducing bioactive substances or drugs,or changing the physical structure of scaffolds by using different spinning processes and parameters to regulate the mechanical properties and cell-behavior induction of scaffolds.In addition,most of the studies are still staying in the laboratory stage.It is an important development direction in the future to promote tissue engineering scaffolds based on PCL fibers with the advantages of low cost and easy processing.
作者
武小童
何儿
刘来俊
李超婧
王璐
王富军
Wu Xiaotong;He Er;Liu Laijun;Li Chaojing;Wang Lu;Wang Fujun(College of Textiles,Donghua University,Shanghai 2Q162Q,China;Key Laboratory of Textile Science&Technology,Ministry of Education,Shanghai 201620,China)
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2020年第5期611-620,共10页
Chinese Journal of Biomedical Engineering
基金
国家重点研发计划(2018YFC1106202)
国家级大学生创新创业训练计划(201910255032)
上海市级大学生创新创业训练计划(sh10255056)。
关键词
聚己内酯
组织工程
纤维
支架
polycaprolactone
tissue engineering
fiber
scaffold
作者简介
通信作者:李超婧,E-mail:lcj@dhu.edu.cn;通信作者:王富军,E-mail:wangfujun@dhu.edu.cn。
