摘要
目的系统评价活血化瘀中药外用对维持性血液透析患者动静脉内瘘功能的影响。方法计算机检索PubMed、Cochrane Library、EMBASE、Web of Science、中国期刊全文数据库(CNKI)、万方数据库、维普数据库和中国生物医学文献服务系统中关于活血化瘀中药外用对维持性血液透析患者动静脉内瘘功能影响的随机对照试验,检索时限为建库至2019年2月。运用Cochrane系统评价手册5.1.0对文献质量进行评价,采用RevMan 5.3软件进行Meta分析。结果共纳入26篇随机对照试验,涉及患者2039例。Meta分析结果显示:活血化瘀中药外用可提高维持性血液透析患者动静脉内瘘皮下血肿治疗有效率[RR=1.25,95%CI(1.19,1.32),P<0.00001]、血管硬结改善率[RR=1.44,95%CI(1.18,1.75),P=0.0003]和血管杂音增强率[RR=1.55,95%CI(1.31,1.83),P<0.00001],降低血管硬结发生率[RR=0.11,95%CI(0.06,0.22),P<0.00001]、血管狭窄发生率[RR=0.32,95%CI(0.20,0.49),P<0.00001]、内瘘闭塞发生率[RR=0.15,95%CI(0.07,0.33),P<0.00001]和假性动脉瘤发生率[RR=0.51,95%CI(0.35,0.75),P=0.0006]。结论活血化瘀中药外用能够有效保护维持性血液透析患者动静脉内瘘功能,降低并发症发生率。
Objective To make a systematic evaluation to the effect of traditional Chinese medicine for activating blood circulation and removing blood stasis for external use on the function of internal arteriovenous fistula in maintenance hemodialysis patients.Methods Randomized controlled trials on the effect of traditional Chinese medicine for activating blood circulation and removing blood stasis for external use on the function of internal arteriovenous fistula in maintenance hemodialysis patients were retrieved in PubMed,Cochrane Library,EMBASE,Web of Science,China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP Database and SinoMed from database establishment to February 2019.Cochrane Handbook for Systematic Reviews of Interventions(Version 5.1.0)was used to evaluate the quality of the literature,and RevMan 5.3 was used for the meta-analysis.Results A total of 26 papers of randomized controlled trials involving 2039 patients were included.The meta-analysis showed that traditional Chinese medicine for activa-ting blood circulation and removing blood stasis for external use,by the functioning of internal arteriovenous fistula in maintenance hemodialysis patients,could improve the effective rate of subcutaneous hematoma treatment[RR=1.25,95%CI(1.19,1.32),P<0.00001],improvement rate of vascular sclerosis[RR=1.44,95%CI(1.18,1.75),P=0.0003]and enhancement rate of vascular murmur[RR=1.55,95%CI(1.31,1.83),P<0.00001],and reduce the incidence of vascular sclerosis [RR=0.11, 95% CI (0.06, 0.22), P<0.000 01], vascular stenosis [RR=0.32, 95% CI (0.20, 0.49), P<0.000 01], internal fistula occlusion [RR=0.15, 95% CI (0.07, 0.33), P<0.000 01] and pseudoaneurysm [RR=0.51, 95% CI (0.35, 0.75), P=0.000 6]. Conclusion Traditional Chinese medicine for activating blood circulation and removing blood stasis for external use can effectively protect the function of internal arteriovenous fistula and reduce the incidence of complications in maintenance hemodialysis patients.
作者
魏宇
宋雅丽
袁丽莎
尹迪
王欢
张云凤
WEI Yu;SONG Yali;YUAN Lisha;YIN Di;WANG Huan;ZHANG Yunfeng(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing100700;Beijing University of Chinese Medicine,Beijing100029)
出处
《上海护理》
2020年第11期15-21,共7页
Shanghai Nursing
基金
北京中医药大学青年教师项目(2018-JYB-JS086)。
关键词
维持性血液透析
动静脉内瘘
活血化瘀
中药外用
META分析
Maintenance hemodialysis
Internal arteriovenous fistula
Activating blood circulation and removing blood stasis
Traditional Chinese medicine for external use
Meta-analysis
作者简介
魏宇(1989-),男,护师,本科,主要从事血液净化护理工作;通信作者:宋雅丽(1987-),女,主管护师,本科,主要从事血液净化护理工作。E-mail:975786425@qq.com。
