摘要
长链非编码RNAs(long non-coding RNAs,lncRNAs)作为一类重要的调控分子,在表观遗传学、转录及转录后等多水平参与免疫反应调控。在抗病毒固有免疫反应中,lncRNAs主要通过与蛋白质、DNA、微小RNA、信使RNA等互作来发挥调节作用;与此同时,病毒亦可通过自身lncRNAs作用于宿主参与免疫逃逸。本文概括了lncRNAs在调控抗病毒固有免疫中的重要作用和相关机制,以及lncRNAs在宿主-病毒互作中免疫逃逸等最新研究进展,以期对病毒感染性疾病提供新的研究思路和诊疗方法。
Long non-coding RNAs(lncRNAs)are critical regulators and modulate immune response epigenetically,transcriptionally and post-transcriptionally.In antiviral innate immunity,lncRNAs mainly exert regulation effect through interaction with proteins,DNAs,miRNAs,mRNAs and so on.Meanwhile,viruses are involved in the immune evasion by their own lncRNAs.This review summarizes the functions and related mechanism of lncRNAs in regulation of innate immune responses and recent advances of lncRNAs mediating immune evasion in the host-viruses interaction,so as to provide a new direction for the studies and therapeutic strategies of viral infectious diseases.
作者
徐睿
姚然然
俞双双
梁佳伟
唐荣淳
张君
XU Rui;YAO Ran-ran;YU Shuang-shuang;LIANG Jia-wei;TANG Rong-chun;ZHANG Jun(NHC Key Laboratory of Medical Immunology,Department of Immunology,School of Basic Medical Sciences,Peking University,100191,China)
出处
《传染病信息》
2020年第5期391-395,400,共6页
Infectious Disease Information
基金
国家自然科学基金(81873871)。
作者简介
通信作者:张君,E-mail:junzhang@bjmu.edu.cn。
