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哺乳动物合子基因组激活调控机制 被引量:2

Regulatory mechanisms on zygotic genome activation in mammals
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摘要 哺乳动物早期胚胎发育是指卵母细胞受精并发育到囊胚的整个过程,雌雄配子在受精后发生迅速重编程形成全能性细胞,重获分化为个体各种类型细胞的潜能[1-5]。早期胚胎基因组处于沉默状态,前几次卵裂是由储存在卵母细胞中的母源因子所调控的,直至合子基因组激活(zygotic genome activation,ZGA),胚胎发育的调控由母源因子向胚胎基因组转换,此过程称为母胚转换(maternalzygote transition,MZT)[6-9]。
作者 张加明 孔庆然 Zhang Jiaming;Kong Qingran
机构地区 温州医科大学
出处 《发育医学电子杂志》 2020年第4期297-303,共7页 Journal of Developmental Medicine (Electronic Version)
基金 浙江省医学技术国家重点研究和一流学科(A类)资助(437601607)。
作者简介 通信作者:孔庆然(Email:kqr721726@163.com)。
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