摘要
目的观察2型糖尿病合并甲状腺结节的发生情况,探讨影响2型糖尿病患者患甲状腺结节的危险因素。方法采用回顾性分析的方法,筛选并收集2016~2018年于兰州大学第一医院内分泌科住院的2033例2型糖尿病患者的临床资料,根据甲状腺超声结果将病例分为有甲状腺结节组和无甲状腺结节组,应用SPSS 20.0软件统计分析。结果2型糖尿病合并甲状腺结节的患者589例,发生率29.0%(男性、女性发生率分别为25.9%、34.3%);多因素Logistic回归分析显示:女性(OR=1.990,P=0.000)、高龄(OR=1.018,P=0.003)、高血压(OR=1.144,P=0.029)、空腹血糖高(OR=0.964,P=0.013)、促甲状腺激素高(OR=1.135,P=0.000)、抗甲状腺球蛋白抗体阳性(OR=1.987,P=0.000)是2型糖尿病患者合并甲状腺结节的危险因素。此外,40~69岁患者容易并存的糖、脂、骨代谢指标的改变。结论女性、高龄、高血压、高血糖、促甲状腺激素高、抗甲状腺球蛋白抗体阳性是2型糖尿病患者合并甲状腺结节的危险因素,可结合其相关代谢指标的改变发现此类患者并及时防治。
Objective To observe the prevalence of type 2 diabetes mellitus complicated with thyroid nodules and to explore the risk factors of thyroid nodules in patients with type 2 diabetes.Methods A retrospective analysis method was used to screen and collect the clinical data of 2033 patients with type 2 diabetes mellitus admitted to the Department of Endocrinology of The First Hospital of Lanzhou University from 2016 to 2018.According to the results of thyroid ultrasound,the cases were divided into thyroid nodules group and non-thyroid nodules group.The data were statistically analyzed using SPSS 20.0 software.Results There were 589 patients with type 2 diabetes and thyroid nodules with a prevalence of 29.0%(25.9%,male;34.3%,female).The multivariate Logistic regression analysis showed that women(OR=1.990,P=0.000)and advanced age(OR=1.018,P=0.003),hypertension(OR=1.144,P=0.029),fasting blood glucose(OR=0.964,P=0.013),high thyroid stimulating hormone(OR=1.135,P=0.000),anti-thyroid ball Positive protein antibody(OR=1.987,P=0.000)is risk factors for thyroid nodules in patients with type 2 diabetes.In addition,changes in sugar,lipid,and bone metabolism are common in patients aged 40-69 years.Conclusion Women,advanced age,hypertension,hyperglycemia,high thyroid-stimulating hormone and anti-thyroglobulin antibody are risk factors for type 2 diabetes patients with thyroid nodules.These patients can be detected in combination with changes in related metabolic indicators and treated in a timely manner.
作者
冯鑫源
田昀灵
傅松波
洪成恩
王雅琨
马小红
张博鑫
汤旭磊
成建国
侯丽杰
Feng Xinyuan;Tian Yunling;Fu Songbo(Department of Endocrinology,The First Hospital of Gansu University,Gansu 730000,China)
出处
《医学研究杂志》
2020年第10期136-140,共5页
Journal of Medical Research
基金
兰州大学学生创新创业行动计划项目(20190060065)。
关键词
2型糖尿病
甲状腺结节
危险因素
Type 2 diabetes mellitus
Thyroid nodules
Risk factors
作者简介
通讯作者:田昀灵,主任医师,电子信箱:13619367318@163.com。
