摘要
设计并制作了同轴共流毛细管微反应器,选用聚(9,9-二辛基芴-共-苯并噻二唑)(PFBT)作为聚合物,四氢呋喃(THF)作为溶剂,去离子水作为反溶剂,聚苯乙烯-马来酸酐共聚物(PSMA)作为稳定剂,结合纳米沉淀法制备聚合物纳米荧光探针,并使用动态光散射仪(DLS)对产物进行表征。结果显示,在操作条件相同,通道尺寸为50~500μm时,通道尺寸越小,越有利于制备小粒径的纳米颗粒;当PFBT的质量浓度为1~50mg/L时,聚合物质量浓度越低,越有利于制备小尺寸的纳米颗粒;在通道尺寸为50μm,PFBT质量浓度为5 mg/L,去离子水与聚合物溶液的流量比为40∶1的条件下,制备的纳米颗粒的尺寸可降到14nm。该技术实现了对纳米颗粒尺寸的精确控制并制备了尺寸更小的聚合物纳米颗粒。
Coaxial co-flow capillary microreactors were designed and constructed.Then,fluorescent polymer dots(Pdots)were prepared by using poly(9,9-dioctylfluorene-co-benzothiadiazole)(PFBT)as polymer,tetrahydrofuran(THF)as solvent,deionized water as antisolvent and polystyrene-maleic anhydride copolymer(PSMA)as stabilizer by a nanoprecipitation method in the microreactors.The products were characterized by dynamic light scattering(DLS)technique.The results showed that under the same operating conditions,the smaller the microchannel size(in the range of 50~500μm),the smaller the nanoparticle size of prepared nanoparticles.When mass concentration of PFBT was 1~50 mg/L,the lower the polymer mass concentration,the more favorable it was for preparing small-sized nanoparticles.Under the conditions of mass concentration of PFBT solution of 5 mg/L,flow ratio of deionized water to polymer solution of 40∶1 and microchannel size of 50μm,the particle size of nanoparticles were reduced to 14 nm.This microfluidic technique can control the size of nanoparticles accurately and produce smaller size of polymer nanoparticles.
作者
杨洲
刘定胜
YANG Zhou;LIU Dingsheng(School of Chemical Engineering,Dalian University of Technology,Dalian 116024,Liaoning,China)
出处
《精细化工》
EI
CAS
CSCD
北大核心
2020年第10期2021-2026,共6页
Fine Chemicals
基金
中央高校基本科研业务费专项基金〔DUT16RC(3)001,DUT19LAB30〕。
关键词
微反应器
聚合物荧光探针
纳米沉淀法
扩散
同轴流动
功能材料
microreactor
fluorescent polymer dots
nanoprecipitation method
diffusion
coaxial flow
functional materials
作者简介
杨洲(1994-),男,硕士生;联系人:刘定胜(1979-),男,副教授,E-mail:dsnu@dlut.edu.cn。
