摘要
目的探讨血清25-羟维生素D与良性阵发性位置性眩晕(BPPV)复发的相关性。方法选取2017年1月至2018年12月该院耳鼻咽喉头颈外科确诊的118例原发性后半规管BPPV患者,所有患者通过手法复位治愈,同时检测其体内血清25-羟维生素D水平。根据血清25-羟维生素D水平,将低于75 nmol/L(或30 ng/mL)的患者按照随机数字表法分为观察组(52例)、对照组(52例),观察组给予补充维生素D治疗,对照组未补充维生素D,在随访期间定期检测两组患者的血清25-羟维生素D水平。所有患者随访1年,观察记录患者的复发情况,评价治疗效果,对比分析其相关影响因素。结果约88.14%的BPPV患者体内血清25-羟维生素D水平呈下降趋势。两组患者治疗前各项指标无明显差异,观察组治疗后血清25-羟维生素D水平逐渐升高并维持在正常水平,而对照组仍存在缺乏或不足。随访期间,观察组复发率比较对照组显著降低,且随着时间的延长,差异越趋明显(χ^2=6.805,P=0.009)。Logistic回归分析显示,血清25-羟维生素D水平与BPPV复发有相关性(OR=0.341,95%CI:0.150~0.774,P=0.009)。结论适当补充维生素D可有效减少BPPV的复发。
Objective To explore the correlation between serum 25-hydroxyvitamin D level and recurrence of benign paroxysmal positional vertigo(BPPV),and the effect of vitamin D supplementation on clinical intervention of BPPV.Methods A selection of 118 patients with primary posterior semicircular canal BPPV diagnosed by the Otorhinolaryngology Head and Neck Surgery in the hospital from January 2017 to December 2018 were selected.All patients were cured by manual reduction and their serum 25-hydroxyvitamin D levels were measured.According to the serum 25-hydroxyvitamin D level,the patients below 75 nmol/L(or 30 ng/mL)were divided into observation group(52 cases)and control group(52 cases)according to the random number table method,and the observation group was given supplements Vitamin D treatment,the control group was not supplemented with vitamin D.During the follow-up period,the serum 25-hydroxyvitamin D levels of the two groups were regularly tested.All patients were followed up for 1 year,the recurrence of all patients was observed and recorded,the treatment effect was evaluated,and related influencing factors were compared and analyzed.Results Serum 25-hydroxyvitamin D levels in most BPPV patients showed a downward trend,accounting for about 88.14%.There was no significant difference in indicators between the two groups before treatment.The serum 25-hydroxyvitamin D level of the observation group gradually increased and maintained at a normal level after vitamin supplementation,while the control group still had deficiency or deficiency.During the follow-up period,the recurrence rate of the observation group was significantly lower than that of the control group,and as the follow-up time was extended,the difference became more obvious(χ^2=6.805,P=0.009).Logistic regression analysis showed that serum 25-hydroxyvitamin D levels are correlated with BPPV recurrence(OR=0.341,95%CI:0.150-0.774,P=0.009).Conclusion Appropriate supplementation of 25-hydroxyvitamin D can effectively reduce the recurrence of BPPV.
作者
黎庆辉
黄艳清
何芸
古金碧
肖斌
袁健
LI Qinghui;HUANG Yanqing;HE Yun;GU Jinbi;XIAO Bin;YUAN Jian(Department of Otolaryngology Head and Neck Surgery,Central Hospital of Jiangjin District,Chongqing 402260,China;Department of Anesthesiology,Central Hospital of Jiangjin District,Chongqing 402260,China)
出处
《重庆医学》
CAS
2020年第19期3220-3224,共5页
Chongqing medicine
基金
重庆市江津区科委基金项目(Y2020044)。
作者简介
黎庆辉(1986-),主治医师,硕士,主要从事耳鸣、眩晕及鼻腔鼻窦肿瘤等方面的研究;通信作者:袁健,E-mail:154817569@qq.com。
