摘要
目的探究高频超声(HFU)、血清甲状腺过氧化物酶抗体(TPO-Ab)对不同性质甲状腺结节诊断的价值。方法选取2019年5月至2020年1月本院122例甲状腺结节(122个结节)患者作为研究对象,根据结节性质分为良性组(n=57)和恶性组(n=65),同期选取60例健康体检者作为对照组。比较三组HFU参数[阻力指数(RI)、搏动指数(PI)、舒张期最低血流速度(D)]、血清TPO-Ab,分析HFU参数及血清TPO-Ab单一及联合诊断价值,并探讨甲状腺结节病理性质的HFU危险因素。结果恶性组D、RI、PI、血清TPO-Ab水平高于良性组、对照组(P<0.05);HFU参数、血清TPO-Ab联合诊断恶性甲状腺结节曲线下面积AUC为0.852,敏感度为73.85%,特异度为84.21%;微钙化、血流信号、似圆度、声晕是恶性甲状腺结节危险因素(P<0.05)。结论微钙化、血流信号>Ⅰ级、似圆度>15、声晕是恶性甲状腺结节发生的独立危险因素,早期采用HFU、血清TPO-Ab联合检查,有助于提高甲状腺结节性质诊断价值。
Objective To explore the value of high-frequency ultrasound(HFU) and serum thyroid peroxidase antibody(TPO-Ab)in the diagnosis of thyroid nodules with different properties. Methods From May 2019 to January 2020,122 patients with thyroid nodules(122 nodules)in our hospital were selected as the research object,and they were divided into the benign group(n=57)and the malignant group(n=65)according to the nature of nodules,during the same period,60 healthy people were selected as the control group. Comparing the HFU parameters[resistance index(RI),pulsatility index(PI),minimum diastolic blood flow velocity(D)],serum TPO-Ab of three groups,analyzing the HFU parameters and serum TPO-Ab single and combined diagnostic value,and exploring the risk factors of HFU in the pathological nature of thyroid nodules. Results The levels of D,RI,PI and serum TPO-Ab in the malignant group were higher than those in the benign group and the control group(P<0.05). The AUC of the area under the curve of the combined diagnosis of HFU parameters and serum TPO-Ab for malignant thyroid nodules was 0.852,the sensitivity was73.85%,and the specificity was 84.21%. Microcalcification,blood flow signal,roundness,and halo were risk factors for malignant thyroid nodules(P<0.05). Conclusion Microcalcification,blood flow signal > grade I,roundness >15,halo are independent risk factors for malignant thyroid nodules. Early combined examination of HFU and serum TPO-Ab was used to improve the diagnostic value of the nature of thyroid nodules.
作者
马纯华
黄畅
郑丹慧
MA Chunhua;HUANG Chang;ZHENG Danhui(Department of Ultrasound,Dafeng hospital,Chaoyang District,Shantou,Guangdong,China,515154)
出处
《分子诊断与治疗杂志》
2020年第9期1171-1174,共4页
Journal of Molecular Diagnostics and Therapy
基金
汕头市科技计划医疗卫生类别项目(190419205263457)。
作者简介
通信作者:马纯华,E⁃mail:13433840862@163.com。
