摘要
目的研究复方缬草舒心滴丸的制备工艺。方法采用滴制法制备滴丸,分别研究基质PEG4000/6000、药物-基质的比例、滴加速度和液体温度等因素对滴丸剂的影响,并以外观性状、重量差异和溶散时限等因素的总评分作为指标进行正交实验研究,优选复方缬草舒心滴丸的最佳制备工艺。结果复方缬草舒心滴丸的最佳成型工艺为:PEG4000/6000(1:1)为基质,药物-基质的比例为1:3,料液温度为90℃,滴加速度为35滴·min^-1,冷凝液液体石蜡温度区间为5~15℃。结论优选的制备工艺稳定可行,可为复方缬草舒心滴丸的制备提供必要的参考。
Objective To study the preparation process of compound Xiecao shuxin dropping pills.Methods Dropping pills were prepared by dropping method.The effects of PEG4000/6000 matrix,drug-matrix ratio,dropping acceleration and liquid temperature on the preparation of the dropping pills were studied.Orthogonal test was conducted with the total scores of appearance,weight difference,and dissolution time as the factors to optimize the best preparation process of compound Xiecao shuxin dropping pills.Results The optimal preparation process of compound Xiecao shuxin dropping pill was as follows:PEG4000/6000(1:1)was as the matrix,and the ratio of drug to matrix was 1:3.The temperature of the feeding liquid was 90℃,and the dropping acceleration was 35 drops per minute,and the temperature range of condensate liquid paraffin was from 5 to 15℃.Conclusion The optimized preparation technology is stable and feasible,which can provide necessary reference for the preparation of compound Xiecao shuxin dropping pills.
作者
周从辉
易爱玲
林园园
叶春生
孙婉瑾
熊义涛
ZHOU Conghui;YI Ailing;LIN Yuanyuan;YE Chunsheng;SUN Wanjin;XIONG Yitao(Department of Pharmacy,Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430061,China;Hubei Province Academy of Traditional Chinese Medicine,Wuhan 430074,China;Department of Pharmacy,People's Hospital of Huangpi District,Wuhan City,Wuhan 430300,China)
出处
《医药导报》
CAS
北大核心
2020年第10期1409-1412,共4页
Herald of Medicine
基金
武汉市科技局关键技术攻关计划项目(2013060602010267)
国家中医药管理局全国中药特色传承人才培训项目(鄂财社发[2015]68号)
湖北省中医院科研专项计划(JDZX2014Y18)。
关键词
复方缬草舒心滴丸
黄芪
缬草
制备工艺
Compound Xiecao shuxin dropping pills
Astragalus membranaceus
Valerian
Preparation process
作者简介
周从辉(1971-),男,湖北鄂州人,副主任药师,硕士,研究方向:中药及复方药物研究。ORCID:0000-0001-5923-6200,电话:027-88920270,E-mail:jovea@126.com;通信作者:熊义涛(1966-),男,湖北广水人,主任药师,研究方向:中药及复方药物研究,电话:027-88920270,E-mail:282690483@qq.com;通信作者:易爱玲(1968-),女,湖北黄陂人,副主任药师,硕士,主要从事药物制剂和中药药理研究。E-mail:1052543089@qq.com。
