胰岛素静脉微量泵入与皮下注射对严重创伤后应激性高血糖患者预后的影响被引量：2

Effect of Intravenous Micro-Infusion Pumping and Subcutaneous Injection of Insulin on the Prognosis of Patients with Severe Post-Traumatic Stress Hyperglycemia

在线阅读下载PDF

导出

摘要目的:对比胰岛素静脉微量泵入与皮下注射对严重创伤后应激性高血糖患者预后的影响。方法:选取2016年7月~2018年6月在本院接受治疗的82例严重创伤后应激性高血糖患者,参照随机数字表法分为A组和B组,每组41例。A组采用间断皮下注射胰岛素治疗,B组采用静脉微量泵入胰岛素治疗,对比两组血糖达标时间、低血糖发生次数、胰岛素总用量、血清K+、Ca 2+浓度及预后情况。结果:B组血糖达标时间、低血糖发生次数及胰岛素总用量均少于A组,有统计学差异(P<0.05);治疗后,B组K+浓度低于A组,Ca 2+浓度高于A组,有统计学差异(P<0.05);B组脓毒血症、多器官功能障碍综合征(MODS)、院内感染发生率及病死率均低于A组,有统计学差异(P<0.05)。结论:胰岛素静脉微量泵入治疗可缩短严重创伤后应激性高血糖患者血糖达标时间,纠正代谢紊乱,减少低血糖发生,改善患者预后。 Objective:To compare the effects of intravenous micro-infusion pumping and subcutaneous injection of insulin on the prognosis of patients with severe post-traumatic stress hyperglycemia.Methods:82 cases of patients with severe post-traumatic stress hyperglycemia treated in the hospital from July 2016 to June 2018 were included in the study and divided into A group and B group by random number table method,with 41 cases in each group.A group was given discontinuous subcutaneous injection of insulin,while B group was treated with intravenous micro-infusion pumping of insulin.The blood glucose reaching standard time,incidents of hypoglycemia,total dosage of insulin,concentration of serum K+and Ca 2+,prognosis were compared between the two groups.Results:The blood glucose reaching standard time,incidents of hypoglycemia,total dosage of insulin in B group were less than those in A group,with significant difference(P<0.05);After treatment,the concentration of K+in B group was lower than that in A group,while the concentration of Ca 2+in B group was higher than that in A group,with significant difference(P<0.05);The incidence of sepsis,multiple organ dysfunction syndrome(MODS),nosocomial infection and case fatality rate in B group were lower than those in A group,with significant difference(P<0.05).Conclusion:Intravenous micro-infusion pumping of insulin in the treatment of patients with severe post-traumatic stress hyperglycemia can shorten the blood glucose reaching standard time,correct metabolism disorders,reduce the incidence of hypoglycemia,and improve the prognosis.

作者胡保芳 HU Bao-fang(Queshan People's Hospital,Zhumadian 463200,China)

机构地区确山县人民医院

出处《中国合理用药探索》 CAS 2020年第9期90-93,共4页 Chinese Journal of Rational Drug Use

关键词应激性高血糖严重创伤胰岛素静脉微量泵入皮下注射预后 stress hyperglycemia severe trauma insulin intravenous micro-infusion pumping subcutaneous injection prognosis

分类号 R977.15 [医药卫生—药品]

作者简介胡保芳,男,主管药师,研究方向:药房、合理用药。E-mail:bcvzq4@163.com。