摘要
目的对比评价2种定量即时检验(POCT)法检测心肌肌钙蛋白I(cTnI)的临床检测效能和可靠性。方法利用国产及进口的2种POCT检测系统同步检测109份血液样本中的cTnI浓度,并对2种检测系统测定的结果进行比较分析。结果国产检测系统检测cTnI的结果为[0.059(0.025,2.845)]ng/ml,灵敏度为98.1%(53/54),特异度为100.0%(55/55),其检测cTnI的阳性率为48.6%;进口检测系统检测cTnI的结果为[0.021(0.001,0.545)]ng/ml,阳性率为49.5%,两者阳性率差异无统计学意义(P=1.00),两系统在结果判定上有较好的一致性(Kappa=0.982,P<0.001)。2种检测系统测定的109例cTnI的数据呈高度相关(r=0.996);两系统检测均为阳性的53例cTnI结果也呈显著相关(r=0.996)。结论国产POCT检测系统在测定cTnI时,具有较高的灵敏度和特异性,适用于心肌梗塞及心肌损伤患者的临床诊断和治疗监测。
Objective To evaluate and compare the clinical performance and reliability of two quantitative point of care testing(POCT)methods in the detection of myocardial troponin I.Methods Myocardial troponin I was detected with two POCT systems(domestic and imported)in 109 whole blood samples and the results of the two detection systems were compared and analyzed.Results The cTnI result of domestic POCT system was(3.91±10.27)ng/ml and it had a high sensitivity(98.1%,53/54)and high specificity(100.0%,55/55).The cTnI result of imported POCT system was(0.668±1.712)ng/ml.The positive rate was 49.5%,and the difference in the positive rate between the two systems was not statistically significant(P=1.00).The two systems had good consistency in the determination of the results(Kappa=0.982,P<0.001).The data of 109 cases of cTnI measured by the two detection systems were highly correlated(r=0.996).There was also a significant correlation between cTnI results in 53 patients who were positive for both systems(r=0.996).Conclusion The domestic POCT system is beneficial for the diagnosis of myocardial infarction and myocardial injury because of its high sensitivity and high specificity in the detection of myocardial troponin I.
作者
甄国东
赵华
ZHEN Guo-dong;ZHAO Hua(Clinical Laboratory,Keqiao District Women and Children's Hospital,Shaoxing,Zhejiang 312030,China)
出处
《中国卫生检验杂志》
CAS
2020年第15期1866-1868,共3页
Chinese Journal of Health Laboratory Technology
关键词
即时检验法
肌钙蛋白I
心肌梗塞
心肌损伤
Point of care testing
Troponin I
Myocardial infarction
Myocardial injury
作者简介
甄国东(1972-),男,本科,主任技师,主要从事临床微生物检验及相关工作。
