摘要
[目的]探讨外周血髓源抑制细胞水平(MDSC)及NLR和PLR比值在结肠癌中的意义。[方法]提取166例结肠癌患者和100名健康体检人员外周血,进行MDSC检测和NLR和PLR检测。[结果]结肠癌组术前MDSC比例明显高于正常组(P<0.05),术后6个月低于术前;结肠癌组术前外周血中NLR水平明显高于正常组(P<0.05),术后6个月显著低于术前(P<0.05);结肠癌组术前外周血中PLR水平明显高于正常组(P<0.05),术后6个月显著低于术前(P<0.05)。MDSC、NLR和PLR水平与结肠癌患者肿瘤大小、TNM分期、淋巴转移有关(P均<0.05)。TNM分期、淋巴转移是影响结肠癌生存的主要因素(P<0.05)。[结论]结肠癌外周血MDSC及NLR和PLR水平明显升高,对预后判断有一定价值。
[Objective] To investigate peripheral blood marrow-derived suppressor cells(MDSC)level,neutrophils-lymphocytes ratio(NLR) and platelets-lymphocytes ratio(PLR) in colon cancer and their significance. [Methods] Peripheral blood samples were collected from 166 colon cancer patients and 100 healthy individuals(control group). The level of MDSC,NLR and PLR was determined. [Results] The proportion of MDSC in the colon cancer group was significantly higher than that in the control group(P<0.05),and the MDSC level of cancer patients 6 months after surgery was significantly lower than that before treatment. The NLR level in the peripheral blood of the colon cancer group was significantly higher than that in the control group(P<0.05),and it was significantly decreased 6 months after surgery compared that before the operation(P<0.05). The PLR level in the peripheral blood of colon cancer group was significantly higher than that in the control group,and it was decreased 6 months after surgery conpared that before the operation(P<0.05). The MDSC,NLR and PLR levels were correlated with tumor size,TNM stage and lymphatic metastasis(P <0.05). TNM stage and lymphatic metastasis were the main factors affecting the survival of colon cancer(P<0.05).[Conclusion] The levels of peripheral blood MDSC,NLR and PLR of colon cancer are increased. It has a certain value for prognosis.
作者
候玥
王燕
蔡静
HOU Yue;WANG Yan;CAI Jing(First People’s Hospital of Longquanyi District,Chengdu 610100,China)
出处
《肿瘤学杂志》
CAS
2020年第8期706-709,共4页
Journal of Chinese Oncology
作者简介
通信作者:蔡静,主治医师,硕士,成都市龙泉驿区第一人民医院肿瘤血液内科,四川省成都市龙泉驿区驿河3组201号(610100),E-mail:184050063@qq.com。
