摘要
目的分析河北省儿童医院2019年呼吸道感染患儿7种常见病毒病原体的流行病学特征,为河北省儿童呼吸道感染的预防和治疗提供理论支持。方法2019年1月1日至12月30日,采集在河北省儿童医院门诊和住院的10186例呼吸道感染患儿的鼻咽部抽吸物(nasopharyngeal aspiration,NPA)或支气管肺泡灌洗液(bronchoalveolar lavage fluid,BALF)。通过基于荧光免疫标记单克隆抗体的免疫荧光法,对呼吸道合胞病毒(respiratory syncytial virus,RSV),腺病毒(adenovirus,ADV),流感病毒(influenza virus,Flu)A、B型,副流感病毒(parainfluenza virus,PIV)Ⅰ、Ⅱ、Ⅲ型进行定性检测。对检出率与性别、年龄及季节的相关性进行统计学分析。结果2019年呼吸道常见病毒总检出率24.66%;RSV检出率最高(7.60%),其后依次是Flu A型(7.10%)、PIVⅢ型(6.54%)、Flu B型(2.01%)、ADV(0.75%)、PIVⅠ型(0.38%)、PIVⅡ型(0.23%)。Flu A型和Flu B型在1~3岁年龄段第一季度(1~3月)检出率最高;ADV在第四季度(9~12月)检出率最高;RSV在1岁以内第四季度(9~12月)检出率最高;PIVⅠ型在第四季度(9~12月)检出率最高;PIVⅢ型在第二季度(3~6月)检出率最高。RSV检出率与年龄因素呈正相关(r=0.200)。Flu A和Flu B检出情况与季节存在相关性(r值分别为0.296和0.170)。结论呼吸道病毒的检出率与年龄段和季节具有一定的相关性。
Objective To analyse the epidemiological features of 7 common pathogens of children with respiratory tract infections in our hospital in 2019,to provide theoretical support for the prevention and treatment of respiratory tract infection children in Hebei province.Methods From January 1,2019 to December 30,2019,nasopharyngeal aspiration(NPA)or bronchoalveolar lavage fluid(BALF)were collected from 10186 outpatient and inpatient children with respiratory tract infection in Children Hospital of Hebei Province.Qualitative detection of RSV,ADV,FIu A,Flu B,and PIVⅠ,PIVⅡ,PIVⅢwas performed by immunofluorescence assay based on fluorescent immunomarker monoclonal antibody.The correlation of detection rate with sex,age and season was analyzed statistically.Results The total detection rate of common respiratory viruses was 24.66%in 2019.The RSV detection rate was the highest(7.60%)than others,followed by Flu A(7.10%),PIVⅢ(6.54%),Flu B(2.01%),ADV(0.75%),PIVⅠ(0.38%),PIVⅡ(0.23%).Flu A and Flu B detections were highest in the first quarter among 1~3 years olds;ADV detection rate was the highest in the fourth quarter;The detection rate of RSV was highest in the fourth quarter among less than 1 years old;PIV I was the most frequently detected in the fourth quarter.PIVⅢhad the highest detection rate in the second quarter.RSV infection was positively correlated with age(r=0.200).Detection of Flu A and Flu B was correlated with seasons(r=0.296,r=0.170).Conclusion The detection rate of respiratory virus has a certain correlation with age and season.
作者
周亮
葛胜旺
Zhou Liang;Ge Shengwang(Pneumology Department,Hebei Children Hospital Affiliated to Hebei Medical University,Shijiazhuang 050000,China;Pathology Department,Hebei Children Hospital Affiliated to Hebei Medical University,Shijiazhuang 050000,China)
出处
《国际儿科学杂志》
2020年第8期578-583,共6页
International Journal of Pediatrics
基金
河北省卫生健康委员会科技技术与发展项目 (20200220)。
关键词
儿童
呼吸道感染
病毒
病原体
流行病学
Children
Respiratory tract infection
Virus
Pathogens
Epidemiology
作者简介
通信作者:周亮,Email:liuzongtai@sina.com。
