摘要
携带荧光探针的药物递送系统在疾病研究中具有同步诊断与治疗的优势。但传统的有机荧光素在高浓度聚集后会出现严重的荧光自淬灭现象,而近年来发现的新型荧光素在高浓度聚集后由于分子内运动受限制,非辐射渠道被抑制,能量以光能的形式释放,产生聚集诱导发光(AIE)现象。基于聚集诱导发光分子的药物递送系统目前已取得良好研究进展,并被用于人类重大疾病的诊治中。本文综述了AIE荧光素用于药物递送以及光动力和光热治疗的研究进展,并对该领域研究面临的挑战和未来方向进行了展望。
Drug delivery systems containing fluorescent probes have the advantage of simultaneous diagnosis and treatment in disease research.Traditional organic fluorescein may exhibit a phenomenon of aggregation caused quenching(ACQ)after aggregation at high concentration.In contrast,it is reported that when a class of fluorescein molecules aggregate in solution,a new phenomenon called aggregation-induced emission(AIE)may occur,because the intramolecular motion is restricted,the non-radiative channel of the molecule is suppressed,and the energy is released in the form of light energy under this circumstance.Drug delivery systems and therapeutic modalities based on AIE fluorescein,termed AIEgen,show promising prospects in detecting and treating life-threatening diseases.This article reviews the research progress of AIE fluorescein in drug delivery,photodynamic and photothermal therapy,and looks forward to the challenges and future directions of research in this field.
作者
张玉权
郭帅
翁郁华
杨勇飞
黄渊余
ZHANG Yuquan;GUO Shuai;WENG Yuhua;YANG Yongfei;HUANG Yuanyu(Key Laboratory of Molecular Medicine and Biotherapy,Advanced Research Institute of Multidisciplinary Science,Institute of Engineering Medicine,School of Life Science,Beijing Institute of Technology,Beijing 100081,China)
出处
《化工学报》
EI
CAS
CSCD
北大核心
2020年第9期4102-4111,共10页
CIESC Journal
基金
国家自然科学基金项目(31871003)。
关键词
聚集诱导发光
有机化合物
纳米材料
光动力治疗
光热治疗
药物
aggregation-induced emission
organic compounds
nanomaterials
photodynamic therapy
photothermal therapy
pharmaceuticals
作者简介
第一作者:张玉权(1997-),男,硕士研究生,yuquan@bit.edu.cn;通信作者:黄渊余(1985-),男,博士,研究员,博士生导师,yyhuang@bit.edu.cn。
