摘要
目的:分析正常育龄妇女巨细胞病毒(CMV)IgG和IgM的检测结果及其临床意义。方法:选取2017年1月-2019年1月本院收治的1179例正常育龄妇女,应用化学发光免疫分析仪对巨细胞病毒IgG和IgM进行检测。分析所有正常育龄妇女的CMV-IgG及CMV-IgM的检测结果。结果:对1179例育龄妇女实施了CMV-IgG检测,检测结果提示,CMV-IgG阳性率为47.2%,其中20~29岁CMV-IgG阳性率为49.9%,高于30~40岁的42.2%,差异有统计学意义(P<0.05)。对1179例育龄妇女实施了CMV-IgM检测,检测结果提示,CMV-IgM阳性率为10.8%,其中20~29岁和30~40岁CMV-IgM阳性率分别为11.1%和10.2%,两者比较,差异无统计学意义(P>0.05)。CMV-IgG和CMV-IgM抗体双阳性标本共120例,高亲和力抗体105例,占比87.5%,中等亲和力抗体11例,占比9.2%,低亲和力抗体4例,占比3.3%。高亲和力抗体占比明显高于中等亲和力抗体、低亲和力抗体。结论:约一半的育龄妇女可能对CMV病毒存在一定的免疫力,在临床中依据需要加强对CMV-IgG及CMV-IgM的监测,实现优生优育,改善妊娠结局。
Objective:To analyze the detection results of cytomegalovirus(CMV)IgG and IgM in women of normal childbearing age and their clinical significance.Method:A total of 1179 women of normal childbearing age admitted to our hospital from January 2017 to January 2019 were selected for the detection of cytomegalovirus IgG and IgM by chemiluminescence immunoanalyzer.The detection results of CMV-IgG and CMV-IgM in all women of normal childbearing age were analyzed.Result:The CMV-IgG test was performed on 1179 women of childbearing age.The test results showed that the CMV-IgG positive rate was 47.2%,and the CMV-IgG positive rate in the 20 to 29 years old group was 49.9%,higher than 42.2%in the 30 to 40 years old group,with statistically significant difference(P<0.05).The CMV-IgM test was performed on 1179 women of childbearing age,the results showed that the positive rate of CMV-IgM was 10.8%,the positive rates of CMV-IgM in 20 to 29 years old group and 30 to 40 years old group were 11.1%and 10.2%,respectively,there was no significant difference between the two groups(P>0.05).There were 120 cases of CMV-IgG and CMV-IgM double positive samples,105 cases of high affinity antibody,accounting for 87.5%,11 cases of medium affinity antibody,accounting for 9.2%,4 cases of low affinity antibody,accounting for 3.3%.The proportion of high affinity antibody was significantly higher than that of medium affinity antibody and low affinity antibody.Conclusion:About half of the women of childbearing age may have some immunity to CMV virus.In clinical practice,the monitoring of CMV-IgG and CMV-IgM should be strengthened according to the need,so as to realize healthy birth and healthy childbearing and improve pregnancy outcome.
作者
孙健
SUN Jian(Jiamusi Maternal and Child Health Hospital,Jiamusi 154004,China)
出处
《中国医学创新》
CAS
2020年第23期65-68,共4页
Medical Innovation of China
作者简介
通信作者:孙健。
