替格瑞洛联合阿司匹林在冠心病患者介入治疗后的应用效果被引量：1

Effects of Ticagrelor combined with Aspirin in treatment of patients with coronary heart disease undergone interventional therapy

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摘要目的:观察替格瑞洛联合阿司匹林在冠状动脉粥样硬化性心脏病(冠心病)患者介入治疗后的应用效果。方法:回顾性分析2017年6月至2019年6月行经皮冠状动脉介入治疗的90例冠心病患者的临床资料,根据手术前后药物治疗方式的不同将其分为对照组与观察组各45例,对照组采取氯吡格雷联合阿司匹林治疗,观察组采取替格瑞洛联合阿司匹林治疗,比较治疗前后两组炎性因子水平、心肌酶谱指标水平、用药期间不良事件发生率与不良反应发生率。结果:治疗后,观察组白介素-6、肿瘤坏死因子-α、C反应蛋白、肌酸激酶同工酶和肌钙蛋白I水平均明显低于对照组,差异有统计学意义(P<0.05);两组用药期间不良事件和不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:替格瑞洛联合阿司匹林治疗冠心病介入治疗患者,可降低炎性因子水平和心肌酶谱指标水平,其效果优于氯吡格雷联合阿司匹林治疗效果。 Objective:To explore effects of Ticagrelor combined with Aspirin in treatment of patients with coronary heart disease undergone interventional therapy.Methods:The clinical data of 90 patients with coronary heart disease who underwent percutaneous coronary intervention from June 2017 to June 2019 were retrospectively analyzed.According to the different drug treatment methods before and after the operation,they were divided into control group and observation group,each with 45 cases.The control group was treated with Clopidogrel combined with Aspirin,while the observation group was treated with Ticagrelor combined with Aspirin.The levels of inflammatory factors,myocardial enzyme spectrum index,the incidence of adverse events and the incidence of adverse reactions during the treatment period were compared between the two groups before and after the treatment.Results:After the treatment,the levels of interleukin-6,tumor necrosis factor-α,C-reactive protein,creatine kinase isoenzyme and troponin I in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the incidence of adverse events and adverse reactions between the two groups during the treatment(P>0.05).Conclusions:Ticagrelor combined with Aspirin in the treatment of the patients with coronary heart disease undergone interventional therapy can reduce the levels of inflammatory factors and myocardial zymogram.Moreover,it is superior to Clopidogrel combined with Aspirin.

作者朱妍 ZHU Yan(The Third Department of Cardiology of the First People’s Hospital of Shenyang,Shenyang 110000 Liaoning,China)

机构地区沈阳市第一人民医院心血管内三科

出处《中国民康医学》 2020年第14期6-8,共3页 Medical Journal of Chinese People’s Health

关键词冠心病替格瑞洛阿司匹林炎性因子心肌酶谱 Coronary heart disease Ticagrelor Aspirin Inflammatory factor Myocardial zymogram

分类号 R541.4 [医药卫生—心血管疾病]

作者简介朱妍(1983.08-),女,辽宁沈阳人,研究生,主治医师,研究方向:心血管内科。