摘要
背景:肿瘤干细胞是肿瘤细胞中数量较少的一类细胞,具有自我更新和分化为不同类型肿瘤细胞的能力。口腔鳞状细胞癌干细胞具有高度的致瘤性,并在肿瘤分化、治疗抵抗、复发和转移中发挥作用,同时肿瘤干细胞与正常干细胞具有极大的相似性,因此有必要建立有效、准确的肿瘤干细胞鉴定方法,设计对应的靶向治疗策略,这有助于口腔鳞状细胞癌患者的预后。目的:总结目前文献中用于鉴定、分离口腔鳞状细胞癌干细胞的方法,分析针对口腔鳞状细胞癌干细胞进行治疗的潜在靶点,并总结这些潜在靶点的研究进展。方法:运用计算机检索中国期刊全文数据库和PubMed数据库,纳入建库以来至2020年发表的相关文献。检索英文关键词为“oral squamous cell carcinoma,OSCC,cancer stem cells,HNSCC,head and neck squamous carcinoma cell”,中文检索词为“口腔鳞状细胞癌干细胞,口腔鳞状细胞癌,肿瘤干细胞,头颈部鳞状细胞癌”。对检索结果进行系统的归纳、总结和分析,并排除相关性低、重复文献和陈旧文献。结果与结论:靶向干预口腔鳞状细胞癌干细胞具有重要的临床意义。CD44、CD133和ALDH是目前最合适的鉴别、分离口腔鳞状细胞癌干细胞的生物标记物,与Oct3/4、Nanog、Sox2、Bmi1、EGFR信号通路、SHH信号通路、Notch信号通路、Wnt信号通路、Let-7家族、MicroRNA-200家族和天然化合物一起作为靶向治疗口腔鳞状细胞癌的潜在靶点。
BACKGROUND:Tumor stem cells are a small number of types of tumor cells that have the ability to self-renew and differentiate into different types of tumor cells.Oral squamous cell carcinoma stem cells are highly tumorigenic and play a role in tumor differentiation,treatment resistance,recurrence and metastasis.Simultaneously,tumor stem cells have great similarities with normal stem cells,so it is necessary to establish effective and accurate tumor stem cell identification methods;and corresponding targeted treatment strategies are designed to help the prognosis of patients with oral squamous cell carcinoma.OBJECTIVE:To summarize the current methods used in the literature to identify and isolate oral squamous cell carcinoma stem cells,analyze potential targets for oral squamous cell carcinoma stem cells,and summarize the potential research progress on targets.METHODS:Computers were used to retrieve the CNKI and PubMed databases for relevant literature published since its establishment to 2020.The English key words were“oral squamous cell carcinoma,OSCC,cancer stem cells,HNSCC,head and neck squamous carcinoma cell”.Chinese key words were“oral squamous cell carcinoma stem cells,oral squamous cell carcinoma,tumor stem cells,head and neck squamous cell carcinoma”.Retrieval results were summarized and analyzed to exclude low-relevance,duplicate,and obsolete documents.RESULTS AND CONCLUSION:Targeted intervention of oral squamous cell carcinoma stem cells has important clinical significance.CD44,CD133 and ALDH are currently the most suitable biomarkers for the identification and isolation of oral squamous cell carcinoma stem cells.They are the same as Oct3/4,Nanog,Sox2,Bmi1,EGFR signaling pathway,SHH signaling pathway,Notch signaling pathway,Wnt signaling pathway,Let-7 family,MicroRNA-200 family and natural compounds together as potential targets for targeted therapy of oral squamous cell carcinoma stem cells.
作者
廖成成
安家兴
谭张雪
王倩
刘建国
Liao Chengcheng;An Jiaxing;Tan Zhangxue;Wang Qian;Liu Jianguo(School of Stomatology,Zunyi Medical University,Zunyi 563000,Guizhou Province,China;Department of Gastroenterology,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China;Special Key Laboratory of Oral Disease Research,Higher Education Institution in Guizhou Province,Zunyi 563000,Guizhou Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2021年第7期1096-1103,共8页
Chinese Journal of Tissue Engineering Research
基金
遵义医学院优秀青年人才项目(17zy-002),项目负责人:王倩
贵州省普通高等学校科技拔尖人才资助项目[黔教合KY(2016)080],项目负责人:王倩
贵州省第六批人才基地《贵州省人才基地——医用生物材料研发》建设项目(RCJD2019-9),项目负责人:刘建国。
作者简介
第一作者:廖成成,男,1995年生,浙江省江山市人,汉族,遵义医科大学在读硕士,主要从事头颈部鳞状细胞癌的研究。;通讯作者:王倩,博士,副教授,贵州省高等学校口腔疾病研究特色重点实验室,贵州省遵义市 563000;共同通讯作者:刘建国,博士,教授,遵义医科大学口腔医学院,贵州省遵义市 563000,贵州省高等学校口腔疾病研究特色重点实验室,贵州省 遵义市 563000
