摘要
纤维肌痛症(fibromyalgia,FM)是一种骨骼肌肉广泛持续性疼痛为主要特征的慢性进展性疾病,临床上往往伴随焦虑、抑郁、睡眠障碍、慢性疲乏或胃肠道功能紊乱等症状。其发病机制仍不明,目前尚无确切疗法,严重影响患者生活质量。近年来研究发现FM与氧化应激、中枢疼痛敏化、转运体蛋白遗传多态性、生物胺含量及功能异常、炎症因子过度释放、肠道菌群紊乱或维生素D缺乏等相关。本文就FM发病机制进行综述,为进一步研究提供参考。
Fibromyalgia(FM)is a syndrome characterized by widely and persistent pain in skeletal muscles,often accompanied by symptoms of anxiety,depression,sleep disturbance,chronic fatigue or gastrointestinal disorder symptoms.Its pathogenesis is still unknown and there is no effective treatment so far,which seriously affects the quality of life of patients.Recent studies have found that fibromyalgia is associated with oxidative stress,central pain sensitization,translocator protein polymorphism,abnormal biogenic amine output and function,excessive release of inflammatory factors,gut microbiota disorders or vitamin D deficiency.This review summarized the pathogenesis of fibromyalgia to provides some clues for further research.
作者
王小梅(综述)
廖丽君(综述)
王清秀(审校)
WANG Xiao-mei;LIAO Li-jun;WANG Qing-xiu(Shanghai East Hospital Clinical Medical College,Nanjing Medical University,Nanjing 210029,China;Dept.of Anesthesiology and Pain management,East Hospital,Tongji University School of Medicine,Shanghai 200120,China)
出处
《同济大学学报（医学版）》
CAS
2020年第4期518-522,共5页
Journal of Tongji University(Medical Science)
基金
国家自然科学基金面上项目(8197081239)
江西省自然科学基金面上项目(20192BAB2050)。
关键词
纤维肌痛症
氧化应激
生物胺
肠道菌群
中枢敏化
转运体蛋白
fibromyalgia
oxidative stress
biogenic amines
gut microbiota
central sensitization
translocator protein
作者简介
王小梅(1991-),女,硕士研究生.E-mail:xiaomeiwang51@163.com;通信作者:王清秀,E-mail:qxw1123@126.com。
