摘要
目的了解哈尔滨市大学生乙型病毒性肝炎(乙肝)血清流行率。方法采用多阶段分层随机抽样法选择哈尔滨市5所高校2014-2018年大学生,采用酶联免疫吸附试验检测乙肝病毒(HBV)血清标志物—HBV表面抗原(HBsAg)、HBV e抗原(HBeAg)、HBV表面抗体(HBsAb)、HBV e抗体(HBeAb)和HBV核心抗体(HBcAb),分析血清流行率。结果本研究共纳入调查对象12697名,五种HBV血清标志物共有8种模式,其中“大三阳”(HBsAg、HBeAg和HBcAb阳性)发生率为0.40%,“小三阳”(HBsAg、HBeAb和HBcAb阳性)发生率为1.51%,五项指标全阴性率为35.39%;HBsAg、HBsAb、HBeAg、HBeAb、HBcAb总阳性率分别为3.56%、61.44%、0.40%、3.75%、4.31%。结论哈尔滨市大学生HBV感染率较低,仍存在一定的HBV易感人群;建议加强大学生乙肝防治知识健康教育,适时开展HepB补充免疫。
Objective To determine the seroprevalence of hepatitis B among college students in Harbin city.Methods We used a multi-stage stratified random sampling method to select students in five colleges of Harbin during 2014-2018.We used enzyme-linked immunosorbent assay to test for hepatitis B virus(HBV)serum markers-HBV surface antigen(HBsAg),HBV e antigen(HBeAg),HBV surface antibody(HBsAb),HBV e antibody(HBeAb),and HBV core antibody(HBcAb).Results In total,12697 subjects were included in the study.Eight patterns of HBV serum markers were identified.Among subjects,0.40%were positive to HBsAg,HBeAg,and HBcAb;1.51%were positive to HBsAg,HBeAb,and HBcAb;and 35.39%were negative to all serum markers.Overall positivity rates for HBsAg,HBsAb,HBeAg,HBeAb,and HBcAb were 3.56%,61.44%,0.40%,3.75%,and 4.31%,respectively.Conclusions The HBV infection rate was low among college students in Harbin,but some students lacked serologic evidence of protection.We suggest health education about hepatitis B prevention and consideration of supplementary hepatitis B vaccination of college students.
作者
张海薇
徐丹
张盼盼
姜美玲
Zhang Haiwei;Xu Dan;Zhang Panpan;Jiang Meiling(First Af filiated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China;Hongqi Hospital,Mudanjiang 157011,Heilongjiang,China)
出处
《中国疫苗和免疫》
北大核心
2020年第3期249-252,共4页
Chinese Journal of Vaccines and Immunization
作者简介
第一作者:张海薇,Email:934809022@qq.com。
