摘要
目的探讨润燥止痒胶囊治疗老年性全身性皮肤瘙痒症的效果及其对患者生活质量的影响。方法选取2019年5月-2020年5月于周浦医院收治的老年全身性皮肤瘙痒症患者80例,采用数字表法随机分为观察组(n=40)和对照组(n=40)。对照组采取咪唑斯汀治疗,观察组在与对照组相同的治疗基础上,加用润燥止痒胶囊。观察并比较2组临床疗效、瘙痒持续时间和程度及面积积分、血清炎性因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]水平、生活质量(DLQI)评分及治疗不良发应发生率等。结果观察组治疗有效率明显高于对照组(P<0.05)。治疗后,观察组瘙痒持续时间明显少于对照组,瘙痒程度及面积积分均明显低于对照组(P<0.05)。治疗后,2组血清IL-6、CRP和TNF-α水平均明显低于同组治疗前,而观察组血清IL-6、CRP和TNF-α水平均明显低于对照组(P<0.05)。2组治疗不良反应发生率差异无统计学意义(5.00%vs 7.5%,P>0.05)。治疗后2组DLQI评分均明显低于同组治疗前,而观察组DLQI评分明显低于对照组(均P<0.05)。结论润燥止痒胶囊可有效治疗老年性全身性皮肤瘙痒症,改善临床症状,降低炎性因子水平,提高患者的生活质量,且安全性较高,具有一定的临床应用价值。
Objective To explore the curative effect of Runzao Zhiyang capsule on elderly patients with systemic skin pruritus and its influences on quality of life of patients. Methods Eighty elderly patients with systemic skin pruritus who were admitted to the Zhoupu Hospital from May 2019 to May 2020 were enrolled. They were randomly divided into control group(n=40) and observation group(n=40). The control group was treated with mizolastine, while observation group was treated with Runzao Zhiyang capsule on basis of control group. The clinical curative effect, pruritus duration, pruritus degree and area integral, serum inflammatory factors [Interleukin-6(IL-6), C-reactive protein(CRP), tumor necrosis factor-α(TNF-α)],score of dermatology life quality(DLQI) and incidence of adverse reactions were observed and compared between the two groups. Results The effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment, the pruritus duration in the observation group was significantly less than that in the control group, and the pruritus degree and area integral in the observation group were significantly lower than those in the control group(P<0.05);the levels of serum IL-6, CRP and TNF-α in the two groups were significantly lower than those in the same group before treatment,while the serum levels of IL-6, CRP and TNF-α in the observation group were significantly lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(5.00% vs 7.5%,P>0.05). After treatment, the DLQI scores of the two groups were significantly lower than those of the same group before treatment, while the DLQI score of the observation group was significantly lower than that of the control group(both P<0.05). Conclusion Runzao Zhiyang capsule can effectively treat elderly systemic skin pruritus, improve clinical symptoms, reduce the level of inflammatory factors, improve the quality of life of patients, and have high safety and has a certain clinical application value.
作者
于越
吴赟
Yu Yue;Wu Yun(Department of Dermatology,Zhoupu Hospital Affiliated to Shanghai College of Medicine and Health Sciences,Pudong New District,Shanghai,201318,P.R.China)
出处
《老年医学与保健》
CAS
2020年第4期670-672,684,共4页
Geriatrics & Health Care
基金
上海市浦东新区卫生系统学科建设项目(PWZZK2017-14)。
关键词
老年
皮肤瘙痒症
润燥止痒胶囊
效果
炎性因子
安全性
生活质量
elderly
skin pruritus
Runzao Zhiyang capsule
effect
inflammatory factor
safety
quality of life
