摘要
目的:探讨阴茎癌患者术后预后的危险因素,为预测阴茎癌术后患者的预后提供更多有价值的信息。方法:回顾性分析2006~2018年于青岛大学附属医院行手术治疗的142例阴茎癌患者的临床资料,包括年龄、吸烟、肿瘤大小、原发部位、TNM分期、组织病理学分级、术前外周血中性粒细胞/淋巴细胞值(neutrophil to lymphocyte ratio,NLR)、淋巴细胞/单核细胞值(lymphocyte to monocyte ratio,LMR)、纤维蛋白原值(fibrinogen level,FIB)、腹股沟病理性淋巴结性质(pathology of inguinal lymph nodes,PL)、手术类型等,利用Kaplan-meier生存分析法计算出总体生存率(overall survival,OS)及肿瘤特异性生存率(cancer specific survival,CSS)并绘制生存曲线,采用单因素及Cox回归模型分析影响阴茎癌患者术后预后的相关因素。结果:阴茎癌手术后患者的3年与5年OS分别为82.9%、75.2%,;3年与5年的CSS分别为89.0%、83.7%;单因素分析结果显示,肿瘤N分期、组织病理学分级、NLR、LMR、FIB、PL可能为影响患者预后的重要因素(P<0.05);经COX比例风险回归模型分析表明PL、FIB为阴茎癌术后患者的独立危险因素。结论:PL阳性、术前外周血高FIB是影响阴茎癌患者预后的独立危险因素,可以作为阴茎癌术后患者预后的有力预测指标。
Objective: To investigate the risk factors of postoperative prognosis of penile cancer patients and provide more valuable information for predicting the prognosis of penile cancer patients. Method: We retrospectively analyzed the data of 142 cases of penile cancer at Department of Urology, Affiliated Hospital of Qingdao University from 2006 to 2018. Data collected included age, smoking, tumor size, the primary site, TNM staging, histopathological grading, the original value of the preoperative blood neutrophil to lymphocytes ratio(NLR), lymphocyte to monocyte ratio(LMR), fibrinogen(FIB) level, pathology of inguinal lymph nodes, type of operation, etc. The overall survival(OS) and cancer-specific survival(CSS) were calculated by Kaplan-meier methods and by drawing the survival curve. Univariable analysis and Cox regression model were used to analyze the prognostic factors of penile cancer. Result: The three-year and five-year OS were 82.9% and 75.2% respectively. The three-year and five-year CSS were 89.0% and 83.7% respectively. Univariate analysis showed that N stage, histopathological grade, preoperative blood NLR, LMR, FIB and pathology of inguinal lymph nodes affected the prognosis of patients(P<0.05). Cox proportional hazard regression analysis showed pathology of inguinal lymph nodes and FIB value were independent influencing risk factors for patients with penile cancer after operation. Conclusion: The positive inguinal lymph nodes and higher preoperative FIB are independent risk factors affecting the prognosis of patients with penile cancer, and they can be used as strong predictors for patients with penile cancer postoperatively.
作者
卜国峰
修子超
邵翠华
孙立江
荆涛
王沛涛
BU Guofeng;XIU Zichao;SHAO Cuihua;SUN Lijiang;JING Tao;WANG Peitao(Medical College of Qingdao University,Qingdao,Shandong,266071,China;Department of Urology,Yancheng First People's Hospital;Department of Obstetrics,Affiliated Hospital of Qingdao University;Department of Urology,Affiliated Hospital of Qingdao University;Department of Andrology,Affiliated Hospital of Qingdao University)
出处
《临床泌尿外科杂志》
2020年第6期426-430,共5页
Journal of Clinical Urology
关键词
阴茎癌
预后
危险因素
penile cancer
prognosis
risk factors
作者简介
通信作者:王沛涛,E-mail:peitaowang@yeah.net。
