宫瘤消胶囊联合达那唑胶囊治疗子宫内膜异位症对患者炎症因子影响被引量：10

Effect of gongliuxiao capsules combined with danazol capsules on the related factors of patients with endometriosis

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摘要目的:探讨宫瘤消胶囊联合达那唑胶囊治疗子宫内膜异位症(EMs)对患者炎性因子水平的影响。方法:选择本院2017年1月-2018年12月收治的EMs患者110例,随机分为对照组与观察组各55例。对照组给予达那唑胶囊治疗,观察组给予达那唑胶囊联合宫瘤消胶囊治疗,均连续治疗3个月。检测两组治疗前后血清前列腺素E2(PGE2)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)、糖类抗原125(CA125)、糖类抗原199(CA199)、血管内皮生长因子(VEGF)、血管生成素-2(Ang-2)、巨噬细胞移动抑制因子(MMIF)、丙二醛(MDA)及超氧化物歧化酶(SOD)水平。结果:治疗后,两组血清PGE2、SOD水平均治疗前提高,TNF-α、IL-1β、MMP-2、MMP-9、CA125、CA199、VEGF、Ang-2、MMIF、MDA水平均治疗前降低,且观察组变化幅度大于对照组(P<0.05)。结论:宫瘤消胶囊联合达那唑胶囊可更好降低EMs患者血清炎症因子水平,有助于血管内皮功能的改善和减轻氧化应激反应。 Objective:To study the effect of gongliuxiao capsules combined with danazol capsules on the related factors of patients with endometriosis.Methods:110 patients with endometriosis were enrolled in this study and were randomly divided into control group and treatment group(55 cases in each group)from January 2017 to December 2018.The patients in the control group were treated with danazol capsules for 3 months,and the patients in the treatment group were treated with gongliuxiao capsules combined with danazol capsules for 3 months.The serum PGE2,TNF-α,IL-1β,MMP-2,MMP-9,CA125,CA199,VEGF,Ang-2,MMIF,MDA,SOD of patients in the two groups before and after treatment were detected and compared.Results:After treatment,the serum PGE2 and SOD levels of patients in the two groups had significantly increased,but the serum levels of TNF-α,IL-1β,MMP-2,MMP-9,CA125,CA199,VEGF,Ang-2,MMIF,and MDA had significantly decreased(P<0.05),and the change of those levels of patients in the treatment group was significant more than those of patients in the control group(P<0.05).Conclusion:Gongliuxiao capsules combined with danazol capsules can reduce the serum levels of inflammatory cytokines of patients with endometriosis,which can help to improve the vascular endothelial function and reduce the oxidative stress reaction of patients.

作者沈萌王璐杨文静陈璐李盛 SHEN Meng;WANG Lu;YANG Wenjing;CHEN Lu;LI Sheng(The sixth Hospital of Wuhan (Affiliated Hospital of Jianghan University),Hubei Province, 430015)

机构地区江汉大学附属医院

出处《中国计划生育学杂志》 2020年第5期710-713,共4页 Chinese Journal of Family Planning

基金 2013年武汉市卫计委临床医学科研项目(WX13C38)。

关键词子宫内膜异位症宫瘤消胶囊达那唑胶囊血管内皮功能炎症因子氧化应激 Endometriosis Gongliuxiao capsules Danazol capsules Vascular endothelial function Inflammatory cytokines Oxidative stress

分类号 R711.71 [医药卫生—妇产科学]

作者简介通讯作者:李盛,Email:lisheng197433@163.com。