摘要
目的研究糖尿病合并新型冠状病毒肺炎(COVID-19)的临床特征。方法采用单中心、回顾性、观察性研究方法,搜集2020年2月23日至3月30日在武汉市雷神山医院感染科三科一病区收治的48例确诊为COVID-19的住院患者,对他们的电子病历进行提取和分析。搜集人口统计学数据、症状、实验室检查、合并疾病、治疗和临床结果。将患者按照是否合并糖尿病分为非糖尿病组和糖尿病组,观察两组患者的临床资料和实验室检查结果,并采用t检验或非参数检验、χ^2检验进行比较。结果COVID-19合并糖尿病的5例患者中,均有发热和呼吸道症状,胸部CT符合典型COVID-19影像学特征,新型冠状病毒核酸检查结果均为阳性。糖尿病组和非糖尿病组COVID-19患者的年龄、性别构成、合并其他疾病、临床症状、临床分型、病程、治疗方案的差异均无统计学意义(P均>0.05)。非糖尿病组和糖尿病组患者的入院空腹血糖差异有统计学意义(P<0.05),糖尿病组出院时空腹血糖与入院时相比差异也具有统计学意义(P<0.05),其他实验室检查指标两组间差异均无统计学意义(P均>0.05)。结论COVID-19合并糖尿病患者以发热和呼吸道症状为主要表现,血糖升高,胸部CT符合典型COVID-19影像学特征。
Objective To study the clinical characteristics of diabetes mellitus with Coronavirus disease 2019(COVID-19)and explore the possible mechanism of diabetes predisposition.Methods A single center,retrospective and observational study was used to collect 48 inpatients diagnosed with COVID-19 who were admitted to the first ward of the third department of infection,Raytheon hospital,Wuhan from February 23,2020 to March 30,2020.Demographic data,symptoms,laboratory tests,comorbidities,treatments and clinical outcomes have been collected.The patients were divided into non-diabetic group and diabetic group according to the combination of diabetes.The clinical data and laboratory test results of the two groups were observed,and the t test,non-parametric test and Chi square test were used for comparison.Results All the 5 patients with COVID-19 diabetes mellitus had fever and respiratory symptoms,chest CT was consistent with typical COVID-19 imaging features,and novel coronavirus nucleic acid test results were positive.There were no statistically significant differences in age,gender composition,co-existing diseases,clinical symptoms,clinical typing,disease course and treatment plan between the diabetic group and the non-diabetic group(P>0.05).There was a statistically significant difference in fasting blood glucose between the non-diabetic group and the diabetic group(P<0.05).The difference of fasting blood glucose at discharge from the diabetes group compared with that at admission was also statistically significant(P<0.05).There was no statistically significant difference between the two groups in other laboratory examination indexes(P>0.05).Conclusions COVID-19 patients with diabetes are mainly manifested by fever and respiratory symptoms.Chest CT shows typical COVID-19 imaging features.
作者
孙海燕
冯晓云
林毅
马宇航
章志建
陈蕊华
王育璠
彭永德
Sun Haiyan;Feng Xiaoyun;Lin Yi;Ma Yuhang;Zhang Zhijian;Chen Ruihua;Wang Yufan;Peng Yongde(Department of Endocrinology and Metabolism,Shanghai First People′s Hospital,Shanghai Jiao Tong University,Shanghai 200080,China)
出处
《中华糖尿病杂志》
CAS
CSCD
北大核心
2020年第7期496-499,共4页
CHINESE JOURNAL OF DIABETES MELLITUS
关键词
糖尿病
2型
新型冠状病毒肺炎
感染
Diabetes mellitus,type 2
Coronavirus disease 2019
Infection
作者简介
通信作者:彭永德,Email:pengyongde0908@126.com。
