摘要
目的观察化瘀养心汤联合针刺“安眠五穴”治疗慢性阻塞性肺疾病(COPD)伴苯二氮类药物依赖性失眠症患者的疗效及对细胞免疫功能的影响。方法将2017年4月—2019年6月西安市中医医院诊治的60例COPD伴苯二氮类药物依赖性失眠症患者随机分为2组,每组30例。2组纳入后均给予常规治疗,对照组在常规疗法治疗基础上给予针刺“安眠五穴”干预,观察组在对照组治疗基础上给予化瘀养心汤干预,均治疗4周。观察2组治疗后中医症状(入寐困难、寐而易醒、醒后不寐、多梦、头昏头痛、心烦心悸、健忘、神疲乏力、面色紫暗)积分、匹兹堡睡眠质量指数量表(PSQI)评分、细胞免疫功能指标、肺功能、生活质量的变化,记录2组临床疗效。结果治疗后2组中医症状积分与总积分、PSQI量表单项评分和总评分均明显降低(P均<0.05),且治疗后观察组上述积分均明显低于对照组(P均<0.05)。治疗后2组CD3+、CD4+、CD4+/CD8+、FVC、FEV1、FEV1/FVC均明显增加(P均<0.05),CD8+和慢性阻塞性肺疾病评估测试评分(CAT)、圣乔治呼吸问卷(SGRQ)评分均明显降低(P均<0.05),且治疗后观察组上述指标改善情况均优于对照组(P均<0.05)。观察组中医症状总有效率为90.0%(27/30)、失眠总有效率为86.7%(26/30),对照组分别为73.3%(22/30)和63.3%(19/30),观察组均明显高于对照组(P均<0.05)。结论化瘀养心汤联合针刺“安眠五穴”治疗COPD伴苯二氮类药物依赖性失眠症不仅可显著改善睡眠障碍,还可提高机体细胞免疫功能,有利于肺功能与生活质量的改善。
Objective It is to observe the therapeutic effect of Huayu Yangxin Decoction combined with acupuncture at“five sleeping points”on chronic obstructive pulmonary disease(COPD)with benzodiazepine-dependent insomnia and its influence on cellular immune function.Methods Sixty patients with COPD with benzodiazepine-dependent insomnia diagnosed and treated in Xi'an Hospital of Traditional Chinese Medicine from April 2017 to June 2019 were randomly divided into 2 groups,30 cases in each group.Both groups were given conventional treatment after enrollment,the control group was treated with acupuncture at“five sleeping points”on the conventional therapy,and the observation group was treated with Huayu Yangxin decoction on the basis of the treatment of the control group,both groups were treated for 4 weeks.The changes of scores of TCM symptoms(difficulty in falling asleep,festless sleep,insomnia after waking up,dreaminess,dizziness,headache,upset and palpitations,forgetfulness,fatigue,and dull complexion),Pittsburgh Sleep Quality Index Scale(PSQI),cellular immune function indexes,lung function,and quality of life after treatment were observed in the two groups,and the clinical efficacy of the two groups was evaluated.Results After treatment,the TCM symptom score and total score,item score and total score of PSQI were significantly reduced(P<0.05),and the above scores of the observation group after treatment were significantly lower than those of the control group(P<0.05).After treatment,the CD3+,CD4+,CD4+/CD8+,FVC,FEV1,FEV1/FVC were significantly increased,and the CD8+and the scores of COPD assessment test(CAT)and St.George’s respiratory questionnaire(SGRQ)were significantly reduced in the two groups(P<0.05),and the improvement of the above indicators in the observation group after treatment was better than that in the control group(P<0.05).The total effective rate of TCM symptoms in the observation group was 90.0%(27/30),the total effective rate of insomnia was 86.7%(26/30),and the rates in the control group were 73.3%(22/30)and 63.3%(19/30)respectively,the rates in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Huayu Yangxin Decoction combined with acupuncture at“five sleeping points”can not only significantly improve sleep disorders,but also improve the body’s cellular immune function,is beneficial to the improvement of lung function and quality of life in the treatment of COPD with benzodiazepine-dependent insomnia.
作者
刘一帆
梅凯
郝建梅
LIU Yifan;MEI Kai;HAO Jianmei(Shaanxi University of Chinese Medicine, Xi’an 710000, Shaanxi, China;Xi’an Hospital of Traditional Chinese Medicine, Xi’an 710000, Shaanxi, China)
出处
《现代中西医结合杂志》
CAS
2020年第21期2310-2315,共6页
Modern Journal of Integrated Traditional Chinese and Western Medicine
作者简介
刘一帆,男,硕士,研究方向为中医内科学肝病;通信作者:郝建梅,E-mail992370200@qq.com。
