摘要
目的探讨系统性红斑狼疮(systemic lupus erythematosus,SLE)肾损伤患者与血清抗核抗体(antinuclear antibody,ANA)荧光模型特征的关系。方法回顾性分析2018年1月至2019年6月绵阳市中心医院SLE患者419例,记录其性别、年龄、随机尿蛋白/肌酐比值(albumin/creatinine ratio,ACR)和抗核抗体检测结果(荧光模型数量、类别及滴度);以ACR判定是否发生肾损伤及损伤程度,将入选对象分为SLE肾损伤和非肾损伤组,尿蛋白中度增多组和尿蛋白重度增多组,比较上述各指标在不同组之间的差异。结果 SLE患者发生肾损伤与性别无关(χ^2=1.33,P=0.248),与年龄大小有关,成年组和老年组差异有统计学意义(χ^2=28.84,P<0.01);入选对象总共检出ANA荧光模型13种,累计763次,SLE肾损伤的发生在不同荧光模型叠加数量(Z=5.27,P<0.01)、类别(χ^2=58.8,P<0.01)及滴度(Z=-6.68,P<0.01)间差异有统计学意义,模型叠加多更易发生肾损伤,核均质型SLE患者更易发生肾损伤,高滴度更易发生肾损伤;SLE肾损伤患者尿蛋白增多程度在不同荧光模型类别(χ^2=-90.83,P<0.01)和叠加数量(Z=-4.36,P<0.01)间差异有统计学意义,核均质型的肾损伤患者ACR值更高,模型叠加多更易造成尿蛋白重度增多。结论特异荧光模型与SLE肾损伤发生及程度有关,SLE肾损伤的防治宜重视患者抗核抗体荧光模型特征的分析。
Objective To explore the relationship between systemic lupus erythematosus (SLE) with renal injury patients and the characteristics of serum antinuclear antibody (ANA) fluorescence model.Methods From January 2018 to June 2019,a retrospective analysis of 419 patients with SLE from Mianyang Central Hospital was performed.The gender,age,random urine protein/creatinine ratio (ACR) and antinuclear antibody test results (number,type and titer of fluorescence model) were recorded.ACR was used to determine whether kidney injury or not and degree of injury.All selected subjects were divided into SLE renal injury and non-renal injury groups,moderately increased urine protein group and severely increased urine protein group.Differences of above indicators among different groups were compared.Results Renal injury in SLE patients was not related to gender(χ^2= 1.33,P =0.248),which was related to age,and the difference between adult and elderly groups was statistically significant(χ^2= 28.84,P<0.01).13 kinds of ANA fluorescence models were detected in all subjects,which was totaled 763 times.SLE renal injury occurred in the number of different fluorescence models (Z = 5.27,P<0.01),category(χ^2= 58.8,P< 0.01) and titer (Z =-6.68,P< 0.01)with statistically significant difference.The more superimposed models were more prone to renal injury.SLE patients with nuclear homogeneous were more prone to renal injury,and high titers were more prone to renal injury.There was a significant difference in the degree of urinary protein increase between different fluorescent model categories(χ^2=-90.83,P<0.01) and the number of superposition (Z =-4.36,P < 0.01).The ACR value was higher in patients with renal injury of nuclear homogeneous type,and the model superimposed more easily caused urine protein severely increased.Conclusion The specific fluorescence model is related to the occurrence and degree of SLE renal injury.The prevention and treatment of SLE renal injury should pay attention to the analysis of the characteristics of patient’s antinuclear antibody fluorescence model.
作者
胡冬
庄利东
陈刚
朱华强
陈曦
Hu Dong;Zhuang Lidong;Chen Gang(Department of Laboratory Medicine,Mianyang Central Hospital,Mianyang,Sichuan 621000,China)
出处
《四川医学》
CAS
2020年第6期581-585,共5页
Sichuan Medical Journal
关键词
系统性红斑狼疮
尿蛋白/肌酐比值
抗核抗体
荧光模型
systemic lupus erythematosus
urine protein/creatinine ratio
antinuclear antibody
fluorescence model
作者简介
通信作者:陈曦,E-mail:hd9898@163.com。
