摘要
目的:观察消疕方联合窄谱中波紫外线(NB-UVB)治疗寻常型银屑病的临床疗效及对氧化应激和微炎症状态的影响。方法:将97例寻常型银屑病患者随机分为观察组(n=49例)和对照组(n=48例),对照组给予常规西医治疗,观察组在对照组基础上给予消疕方+NB-UVB治疗,疗程为8周。比较两组临床疗效、中医症候积分、银屑病面积与严重性指数(PASI)评分、皮肤病生活质量指数(DLQI)评分、氧化应激和炎性反应指标。结果:观察组临床疗效显著高于对照组(91.84%vs 72.92%,P<0.05);两组治疗后瘙痒、鳞屑、红斑、心烦易怒、口干口渴、中医证候总积分均显著降低(P<0.05),观察组治疗后各中医症候积分均低于对照组(P<0.05);两组治疗后PASI评分显著降低,观察组治疗后积分低于对照组(P<0.05);两组治疗后日常活动、生理状态、社交娱乐、心理状态和DLQI总评分均显著降低(P<0.05),观察组治疗后以上评分均低于对照组(P<0.05);两组治疗后血清CAT、SOD、GSH-PX水平均显著升高,MAD、IL-6、IL-8、TNF-α、VGEF水平显著降低,观察组治疗后以上指标改善情况均优于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论:在西医治疗基础上采用消庀方+NB-UVB治疗能够显著缓解寻常型银屑病患者临床症状,改善生活质量,提高临床疗效,且用药安全,其机制之一可能与其抑制机体炎性反应和氧化应激有关。
Objective:To observe the efficacy of using Xiaopi Decotion combined with NB-UVB in the treatment of psoriasis vulgaris and its effect on oxidative stress and micro-inflammatory state.Methods:97 cases of patients with psoriasis vulgaris were randomly divided into observation group(n=49 cases) and controlled group(n=48 cases) and the controlled group was given conventional western medicine treatment, the observation group was given Xiaopi Decotion combined with NB-UVB on the basis of the controlled group, course of 8 weeks.The clinical efficacy, TCM syndromes score, psoriasis area and severity index(PASI) score, skin disease quality of life index(DLQI) score, oxidative stress and inflammatory reaction index of the two groups were compared.Results:the clinical efficacy of the observation group was significantly higher than that of the controlled group(91.84% vs 72.92%, P<0.05).The two groups after treatment of itching, scales, erythema, upset, irritability, dry mouth, thirst, TCM syndrome total score were significantly lower(P<0.05), the observation group after treatment of the above points were lower than the controlled group(P<0.05);PASI score of the two groups significantly decreased after treatment, and the score of the observation group was lower than that of the controlled group after treatment(P<0.05).After treatment, the total scores of daily activities, physiological status, social entertainment, psychological status and DLQI in both groups were significantly decreased(P<0.05), and the above scores in the observation group were lower than those in the controlled group(P<0.05).Serum CAT, SOD and GSH-PX levels were significantly increased in both groups after treatment, and the levels of MAD, IL-6, IL-8, TNF-length and VGEF were significantly decreased in both groups after treatment, and the improvement of the above indicators in the observation group was better than that in the controlled group after treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:On the basis of western medicine adopt Xiaopi Decotion combined with NB-UVB can significantly relieve the clinical symptoms of patients with psoriasis vulgaris, to improve the quality of life, improve the clinical curative effect, and drug safety, and one of its mechanisms may suppress the inflammatory reaction and oxidative stress.
作者
徐萱
XU Xuan(The Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu 212000,China)
出处
《四川中医》
2020年第6期174-178,共5页
Journal of Sichuan of Traditional Chinese Medicine
关键词
消疕方
寻常型银屑病
氧化应激
炎症反应
Xiaopi Decotion
NB-UVB
Psoriasis vulgaris
Oxidative stress
Inflammatory response
